Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia

Metabolism: Clinical and Experimental
Andreas OberbachHolger Till

Abstract

Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight following laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y-gastric bypass (RYGB) in severely obese adolescents. 10 severely obese adolescents underwent either LSG (n=5) or RYGB (n=5). 17 normal weight, healthy, age- and gender-matched adolescents served as a normal weight peer group (NWPG). Pre- and 12 months postoperatively, sUA and relevant metabolic parameters (glucose homeostasis, transaminases, lipids) were compared. Preoperatively, sUA was significantly elevated in patients with severe obesity compared to NWPG. Twelve months after LSG and RYGB, a significant decrease in sUA, BMI, CVD risk factors, hepatic transaminases, and HOMA-IR was observed. Reduction in SDS-BMI significantly correlated with changes in sUA. sUA levels and metabolic comorbidities improved following bariatric surgery in severely obese adolescents. The impact of changes in sUA on long-term clinical complications of childhood obesity deserves further ...Continue Reading

References

Dec 4, 1991·JAMA : the Journal of the American Medical Association·F FacchiniG M Reaven
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Jan 1, 1997·American Journal of Hypertension·V LaheraL M Ruilope
Mar 4, 2003·European Journal of Endocrinology·Juan J Díez, Pedro Iglesias
Jan 13, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Christian DenzerMartin Wabitsch
Feb 7, 2004·Current Diabetes Reports·Martha L Cruz, Michael I Goran
Dec 8, 2004·Journal of the American College of Cardiology·Piero O BonettiAmir Lerman
Jan 22, 2005·Seminars in Nephrology·John Kanellis, Duk-Hee Kang
Mar 21, 2006·Obesity Surgery·John MelissasElias Castanas
May 6, 2006·Stroke; a Journal of Cerebral Circulation·Michiel J BosMonique M B Breteler
Dec 16, 2006·Endothelium : Journal of Endothelial Cell Research·Dimitris TousoulisChristodoulos Stefanadis
Apr 3, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mehmet Emre Atabek, Ozgur Pirgon
Aug 30, 2008·JAMA : the Journal of the American Medical Association·Daniel I FeigRichard J Johnson
Sep 12, 2008·American Journal of Physiology. Cell Physiology·Sergey ZharikovJawaharlal Patel
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Oct 28, 2008·European Journal of Endocrinology·Lucia PacificoClaudio Chiesa
Apr 21, 2009·The Journal of Pediatrics·Stephanie NguyenChi-yuan Hsu
Jun 13, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kyung Mee KimRichard J Johnson
Feb 23, 2010·Nature Reviews. Endocrinology·Ram Weiss
Mar 1, 2013·Annals of Nutrition & Metabolism·Manabu IshiroHiroshi Tamai
Jun 5, 2013·The Journal of Clinical Hypertension·Vikram AgarwalFranz H Messerli
Jul 3, 2013·Current Opinion in Pediatrics·Sean J Barnett

❮ Previous
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Citations

Sep 11, 2014·Current Treatment Options in Cardiovascular Medicine·Jackson H CoppockDenise E Wilfley
Apr 7, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Harold BaysCraig Primack
Jan 26, 2016·Metabolism: Clinical and Experimental·Stergios A Polyzos, Christos S Mantzoros
Nov 4, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A-C PaepegaeyC Poitou
Jan 1, 2015·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros
Sep 10, 2014·Clinical Orthopaedics and Related Research·Bryce A BasquesJonathan N Grauer
Aug 11, 2016·Metabolism: Clinical and Experimental·Xi XiaFengxian Huang
Sep 23, 2016·Surgical Neurology International·Michael D Wider
Feb 16, 2017·Biological Research for Nursing·V E Fernández-RuizJ Mulero
Jun 22, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A S ShahT H Inge
Jun 12, 2018·Postgraduate Medicine·Claudio TanaTiziana Meschi
Aug 31, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Charleen YeoDanson Yeo
May 2, 2018·Journal of Diabetes Research·Paulina SamczukAdam Kretowski
May 1, 2021·International Journal of Molecular Sciences·Revathy CarnagarinMarkus P Schlaich
Jun 3, 2021·Children·Valeria CalcaterraFatima Cody Stanford
Jun 3, 2021·Children·Holger TillSusann Weihrauch-Blüher

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