Barium plateau potentials of CA1 pyramidal neurons elicit all-or-none extracellular alkaline shifts via the plasma membrane calcium ATPase.

Journal of Neurophysiology
Sachin Makani, M Chesler

Abstract

In many brain regions, synchronous neural activity causes a rapid rise in extracellular pH. In the CA1 region of hippocampus, this population alkaline transient (PAT) enhances responses from postsynaptic, pH-sensitive N-methyl-d-aspartate (NMDA) receptors. Recently, we showed that the plasma membrane Ca(2+)-ATPase (PMCA), a ubiquitous transporter that exchanges internal Ca(2+) for external H(+), is largely responsible for the PAT. It has also been shown that a PAT can be generated after replacing extracellular Ca(2+) with Ba(2+). The cause of this PAT is unknown, however, because the ability of the mammalian PMCA to transport Ba(2+) is unclear. If the PMCA did not carry Ba(2+), a different alkalinizing source would have to be postulated. Here, we address this issue in mouse hippocampal slices, using concentric (high-speed, low-noise) pH microelectrodes. In Ba(2+)-containing, Ca(2+)-free artificial cerebrospinal fluid, a single antidromic shock to the alveus elicited a large (0.1-0.2 unit pH), "all-or-none" PAT in the CA1 cell body region. In whole cell current clamp of single CA1 pyramidal neurons, the same stimulus evoked a prolonged plateau potential that was similarly all-or-none. Using this plateau as the voltage command in...Continue Reading

References

Aug 13, 1979·Biochemical and Biophysical Research Communications·S G O'NealE Racker
May 1, 1975·The Journal of General Physiology·S HagiwaraO Sand
Nov 1, 1979·The Journal of Physiology·A L Gorman, A Hermann
Jan 1, 1976·The Journal of Physiology·R Eckert, H D Lux
May 1, 1992·The American Journal of Physiology·B X ZhangS Muallem
Jan 1, 1992·Journal of Neurophysiology·J C Chen, M Chesler
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J C Chen, M Chesler
Jan 1, 1991·Physiological Reviews·E Carafoli
Nov 1, 1990·The Journal of General Physiology·J TytgatE Carmeliet
Jun 1, 1988·Neuroscience·B Rudy
Jun 1, 1988·Archives of Biochemistry and Biophysics·D Zhao, N S Dhalla
Jan 1, 1984·Progress in Biophysics and Molecular Biology·R Eckert, J E Chad
Nov 1, 1982·The Journal of General Physiology·C M ArmstrongS R Taylor
Mar 1, 1984·Cellular and Molecular Neurobiology·J A Connor, Z Ahmed
Jul 1, 1983·The Journal of Physiology·J Hounsgaard, C Nicholson
Nov 1, 1996·The Journal of General Physiology·X H ChenR W Tsien
Jan 12, 2001·Physiological Reviews·E E Strehler, D A Zacharias
Mar 14, 2002·The Journal of Membrane Biology·A Leaf, Y F Xiao
Sep 1, 1964·The Journal of General Physiology·S HAGIWARA, K I NAKA
Sep 25, 2003·Physiological Reviews·Mitchell Chesler
Jul 24, 2004·The Journal of Physiology·Anthony J A MolinaRobert Paul Malchow
Jul 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sachin Makani, Mitchell Chesler
Aug 1, 2007·The Journal of General Physiology·Matthew A KreitzerRobert Paul Malchow
Sep 22, 1993·Proceedings. Biological Sciences·C J SchwieningR C Thomas
Nov 27, 2009·Journal of Neurophysiology·Sachin Makani, Mitchell Chesler

❮ Previous
Next ❯

Citations

Jun 11, 2019·Synapse·Osvaldo D UchitelCarina Weissmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.