Barium sulphate with a negative zeta potential accelerates skin permeability barrier recovery and prevents epidermal hyperplasia induced by barrier disruption

The British Journal of Dermatology
Shigeyoshi FuziwaraM Denda

Abstract

Barium sulphate, a stable inorganic material, has been used in contrast media and cosmetic products because of its stability. As a negative external electric potential accelerates the skin barrier repair after barrier disruption, we hypothesized that topical application of barium sulphate may affect the skin barrier recovery rate depending on its zeta potential. To investigate whether barium sulphate particles in aqueous solution have different zeta potentials depending on their surface structure, and to investigate the possible relation between zeta potential and skin barrier recovery rate. Mice were subjected to tape stripping to disrupt barrier function, or were treated with acetone and kept in a dry environment to induce epidermal hyperplasia. They were then treated with different forms of barium sulphate, and barrier recovery was monitored by measurements of transepidermal water loss. There was a significant correlation between the barrier recovery rate and zeta potential of barium sulphate applied topically. Barium sulphate with a negative zeta potential significantly accelerated barrier recovery, but barium sulphate with a positive zeta potential did not accelerate or even delayed barrier repair. Barium sulphate with a n...Continue Reading

References

Feb 1, 1992·The Journal of Clinical Investigation·S H LeeK R Feingold
May 1, 1994·The Journal of Investigative Dermatology·G K MenonK R Feingold
Nov 7, 1999·Archives of Dermatological Research·M DendaM Takahashi
May 16, 2000·The British Journal of Dermatology·M Denda, T Tsuchiya
Jun 29, 2000·Biochemical and Biophysical Research Communications·M DendaY Asida
Aug 18, 2001·Skin Pharmacology and Applied Skin Physiology·P M Elias, K R Feingold
Nov 26, 2002·The Journal of Investigative Dermatology·Peter M EliasKenneth R Feingold

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Citations

Aug 2, 2013·Journal of Dispersion Science and Technology·Vuk Uskoković
Aug 7, 2009·Cell and Tissue Research·Moe TsutsumiMitsuhiro Denda
Jan 30, 2009·International Journal of Cosmetic Science·M Denda
Sep 16, 2009·The British Journal of Dermatology·M Denda, M Nakatani
Dec 17, 2009·Experimental Dermatology·Mitsuhiro Denda, Noriyuki Kumazawa
Nov 3, 2021·Experimental Dermatology·Mitsuhiro Denda, Shinobu Nakanishi

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