PMID: 2891531Jan 1, 1987Paper

Baroreceptor function in man following peripheral alpha 1- and alpha 2-adrenoceptor stimulation

European Journal of Clinical Pharmacology
A H DeeringD W Harron


Methoxamine and alpha-methyl-noradrenaline were administered to six healthy male subjects on separate days as rapid bolus injections until blood pressure increased by approximately 30 mmHg; Valsalva's Manoeuvre was carried out on each occasion. Propranolol (80 mg) or placebo was administered (random order, double-blind, weekly intervals) and the observations were repeated after 2 h. Baroreceptor sensitivity (delta R-R interval ms/mmHg systolic BP) was less (p less than 0.05) with alpha-methyl-noradrenaline than methoxamine. Propranolol abolished the differences in baroreceptor-mediated bradycardia following alpha-methyl-noradrenaline and methoxamine, and shifted the baroreceptor sensitivity regression lines (p less than 0.05) to the left. During the release phase of Valsalva's Manoeuvre baroreceptor sensitivity was increased following propranolol. The smaller baroreceptor-mediated bradycardia response observed with alpha-methyl-noradrenaline does not support the hypothesis that pre-synaptic alpha-adrenoreceptors have a physiological role in the modulation of baroreceptor function in man, and may be due to alpha-methyl-noradrenaline having beta 1-agonist activity.


Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Sep 1, 1977·Clinical Pharmacology and Therapeutics·G SimonS Julius
Jan 1, 1979·British Heart Journal·R T Krediet, A J Dunning
Sep 1, 1976·Journal of Applied Physiology·P M GrossK Wasserman
Sep 1, 1976·Journal of Applied Physiology·D L EckbergA L Mark
Nov 1, 1985·British Journal of Clinical Pharmacology·D W HarronR G Shanks
Dec 1, 1985·British Journal of Clinical Pharmacology·M J BrownD C Brown
Feb 1, 1972·Circulation Research·T G PickeringP Sleight
Feb 1, 1981·Clinical Pharmacology and Therapeutics·G A FitzGeraldC T Dollery
May 1, 1982·Clinical Cardiology·D T O'Connor, R A Preston

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