PMID: 6169391Sep 14, 1981Paper

Baroreflex actions of substance P microinjected into the nucleus tractus solitarii in rat: a consequence of local distortion

Brain Research
W T Talman, D J Reis

Abstract

Biologically active substance P (SP) (1000 ng in 0.1 microliter saline) microinjected into the nucleus tractus solitarii (NTS) of 25 rats did not affect arterial pressure, heart rate, or the baroreceptor reflex. However, microinjection of saline alone in volumes greater than 0.3 microliter consistently elicited hypotension and bradycardia followed occasionally by transient hypertension. These data suggest that previously reported cardiovascular effects of SP microinjected into the NTS resulted from local distortion.

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Citations

Mar 18, 1983·European Journal of Pharmacology·L CriscioneW T Talman
Sep 10, 1985·European Journal of Pharmacology·J HednerG R Breese
Mar 29, 1988·European Journal of Pharmacology·M Laubie, H Schmitt
Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Feb 9, 1995·Journal of the Autonomic Nervous System·F MartiniJ J Puizillout
Jan 1, 1990·Progress in Neurobiology·M KumadaT Kuwaki
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·R B Raffa
Nov 6, 1996·Journal of the Autonomic Nervous System·A M McKernan, F R Calaresu
May 2, 2000·Journal of the Autonomic Nervous System·J L SeagardF A Hopp
Jan 1, 1991·Clinical Neurology and Neurosurgery·J J van Hilten, R A Roos
Mar 1, 1983·Acta Physiologica Scandinavica·J HednerJ Jonason
Mar 22, 2014·Physiology & Behavior·Guillaume de Lartigue
May 12, 2004·Peptides·Cinda J Helke, Jeanne L Seagard
Dec 19, 2012·Autonomic Neuroscience : Basic & Clinical·William T Talman, Li-Hsien Lin
Oct 26, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C ZhangB H Machado
Jan 1, 1989·Circulation Research·C J TsengD Robertson
Jan 1, 1993·Circulation Research·R Mosqueda-GarciaR M Robertson
Dec 7, 2002·Hypertension·Jeffrey RileyWilliam T Talman

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