Baroreflex Activation Therapy in Heart Failure With Reduced Ejection Fraction: Available Data and Future Perspective

Current Heart Failure Reports
Marcel HalbachH Reuter

Abstract

Progression of heart failure with reduced ejection fraction (HFrEF) is promoted by sympathovagal imbalance. Baroreflex activation therapy, i.e., electrical stimulation of baroreceptors at the carotid sinus, can restore sympathovagal balance. Large animal studies of baroreflex activation therapy revealed improvements in cardiac function, susceptibility to ventricular arrhythmias, and a survival benefit as compared to untreated controls. Recently, the first randomized and controlled trial of optimal medical and device therapy alone or plus baroreflex activation therapy in patients suffering from HFrEF was published. It demonstrated a reasonable safety profile in this severely ill patient population. Moreover, the study found significant improvements in New York Heart Association class, quality of life, 6-min walk distance, and NT-proBNP levels. This review provides an overview on baroreflex activation therapy for the treatment of HFrEF-from the concept and preclinical findings to most recent clinical data and upcoming trials.

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Citations

Sep 28, 2017·Current Cardiology Reports·Brett G AngelLuke S Kusmirek
Feb 13, 2018·Heart Failure Reviews·Jasneet DevgunWaqas Ghumman
Jan 31, 2019·Frontiers in Cardiovascular Medicine·Jacobus F BensonGregory R Tintinger
Oct 21, 2017·European Journal of Preventive Cardiology·Nina Japundžić-ŽigonDavid Murphy

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