Abstract
Progression of heart failure with reduced ejection fraction (HFrEF) is promoted by sympathovagal imbalance. Baroreflex activation therapy, i.e., electrical stimulation of baroreceptors at the carotid sinus, can restore sympathovagal balance. Large animal studies of baroreflex activation therapy revealed improvements in cardiac function, susceptibility to ventricular arrhythmias, and a survival benefit as compared to untreated controls. Recently, the first randomized and controlled trial of optimal medical and device therapy alone or plus baroreflex activation therapy in patients suffering from HFrEF was published. It demonstrated a reasonable safety profile in this severely ill patient population. Moreover, the study found significant improvements in New York Heart Association class, quality of life, 6-min walk distance, and NT-proBNP levels. This review provides an overview on baroreflex activation therapy for the treatment of HFrEF-from the concept and preclinical findings to most recent clinical data and upcoming trials.
References
Dec 14, 1967·The New England Journal of Medicine·E BraunwaldN S Braunwald
Oct 16, 1969·The New England Journal of Medicine·E Braunwald, B E Sobel
Jul 1, 1982·Circulation Research·A A Shoukas
Mar 22, 2001·The New England Journal of Medicine·S CazeauUNKNOWN Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators
Jun 29, 2001·European Heart Journal·H P Brunner-La RoccaD M Kaye
Sep 12, 2007·Hypertension·Irving H ZuckerMartin A Rossing
Jan 27, 2010·Hypertension·Karsten HeusserJens Jordan
Nov 26, 2010·Circulation. Heart Failure·Hani N SabbahRobert S Kieval
Apr 23, 2011·Journal of the American College of Cardiology·John D BisognanoUNKNOWN DEBuT-HT and Rheos Feasibility Trial Investigators
Feb 22, 2012·Journal of the American Society of Hypertension : JASH·George L BakrisJohn D Bisognano
Apr 25, 2012·Current Cardiology Reports·Hani N Sabbah
Jul 26, 2012·European Journal of Heart Failure·John J V McMurrayUNKNOWN ESC Committee for Practice Guidelines
Feb 5, 2014·Journal of the American College of Cardiology·Andrew P AmbrosyMihai Gheorghiade
Feb 15, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Navid MadershahianThorsten Wahlers
May 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Steven BurgoyneJohn V Tyberg
Jul 30, 2014·European Journal of Heart Failure·Edoardo GrondaGuido Grassi
May 20, 2015·JACC. Heart Failure·William T AbrahamWilliam C Little
May 27, 2015·European Journal of Heart Failure·Michael R ZileWilliam C Little
Jul 2, 2015·Journal of Hypertension·Edoardo GrondaGuido Grassi
Jul 5, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ramin ShadmanWayne C Levy
Jul 8, 2015·Nature Reviews. Cardiology·Ronald G Victor
Citations
Sep 28, 2017·Current Cardiology Reports·Brett G AngelLuke S Kusmirek
Feb 13, 2018·Heart Failure Reviews·Jasneet DevgunWaqas Ghumman
Mar 12, 2019·Kardiologiia·T M UskachR S Akchurin
Jan 23, 2020·ESC Heart Failure·Rodrigo SchmidtMaria Claudia Costa Irigoyen
Aug 25, 2017·Der Internist·M KoziolekH Reuter
Jan 31, 2019·Frontiers in Cardiovascular Medicine·Jacobus F BensonGregory R Tintinger
Oct 21, 2017·European Journal of Preventive Cardiology·Nina Japundžić-ŽigonDavid Murphy
Aug 18, 2018·American Heart Journal·Michael R ZileElizabeth G Galle
Feb 28, 2019·Life Sciences·Jing WangMingwei Bao