Abstract
The cardiac hypertrophy observed in hypertension is thought to be responsible for the accompanying deficiency in the baroreflex control of heart rate. In this study, we assessed the baroreflex relationship between heart rate and arterial pressure on a group of seven rabbits during a normotensive period, during the early phase of angiotensin II (Ang II)-induced hypertension II week) (50 ng/kg per minute i.v. via osmotic minipumps), after 7 weeks of continuous hypertension, then 2 days after Ang II was stopped, and finally 7 days after Ang II. Left ventricles were weighed for measurement of left ventricular weight-body weight ratio. One week of intravenous Ang II infusion produced hypertension (mean arterial pressure from 80 +/- 2 up to 115 +/- 8 mm Hg), with significantly increased heart rate and hematocrit. The heart rate-arterial pressure baroreflex curve was shifted to the right, with a significant 45% reduction in the gain of the reflex (-6.4 +/- 1.5 to -3.5 +/- 0.2 beats per minute/mm Hg). After 7 weeks of Ang II, arterial pressure was still elevated (112 +/- 4 mm Hg) and the gain of the baroreflex curve still somewhat attenuated, although it was no longer markedly different from normotensive levels (gain, -5.09 +/- 0.95, 2...Continue Reading
References
Sep 1, 1979·Acta Physiologica Scandinavica·P ThorénS E Ricksten
Sep 1, 1991·Journal of the American College of Cardiology·T G FarrellA J Camm
Aug 1, 1989·Hypertension·M A AdamsP I Korner
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·C GiannattasioG Mancia
Sep 1, 1988·Hypertension·G GrassiG Mancia
Nov 1, 1985·Hypertension·K M Denton, W P Anderson
Dec 1, 1987·Journal of the Autonomic Nervous System·G A Head, R McCarty
Feb 1, 1973·Circulation Research·J E Angell-James
May 1, 1995·Canadian Journal of Physiology and Pharmacology·L FanE W Quillen
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·P I Korner
Apr 1, 1995·Clinical Science·H el-Sayed, R Hainsworth
Oct 1, 1994·Clinical and Experimental Pharmacology & Physiology·G A Head
Aug 1, 1994·The American Journal of Physiology·T DalkaraM A Moskowitz
May 1, 1993·Journal of Applied Physiology·M P McDonaldG K Savard
Citations
Sep 21, 2000·Pathophysiology : the Official Journal of the International Society for Pathophysiology·S C Tyagi
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·G A Head, S L Burke
Sep 5, 2002·Clinical and Experimental Pharmacology & Physiology·Rohit RamchandraSimon C Malpas
Jul 15, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masato NishimuraToshihiko Ono
Aug 7, 2001·Journal of Cardiovascular Pharmacology·Z Z ShanD F Su
Jan 13, 2004·Journal of Cardiovascular Pharmacology·Zheng-Zheng ShanDing-Feng Su
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Sarah-Jane GuildSimon C Malpas
Aug 30, 2008·Epilepsia·Cameron S MetcalfSteven L Bealer
Apr 2, 2015·Journal of Hypertension·Dongze ZhangYu-Long Li
Feb 25, 2014·Autonomic Neuroscience : Basic & Clinical·Elizabeth B Oliveira-SalesJulian F R Paton
Apr 4, 2014·Laboratory Animals·C T BusseyR R Lamberts
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon C MalpasCarolyn J Barrett
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah-Jane GuildRoger G Evans
Sep 12, 2019·Clinical and Experimental Pharmacology & Physiology·Emmanuel Veríssimo de AraújoJosé Luiz de Brito Alves
Sep 5, 1998·The American Journal of Physiology·P LantelmeM Ducher
Sep 14, 1999·The American Journal of Physiology·Z Z ShanD F Su
Jun 8, 2018·Frontiers in Physiology·Alynne Carvalho-GalvãoValdir A Braga
Oct 23, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KobaTatsuo Watanabe
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·E GaudetG A Head
Sep 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Radu IliescuJane F Reckelhoff