PMID: 8586806Oct 1, 1995Paper

Baroreflex control of heart rate in Dahl hypertensive (SS/Jr) and normotensive (SR/Jr) rats

Journal of Hypertension
C A Murphy, R McCarty

Abstract

To determine whether impaired reflex control of heart rate was evident in rats of the inbred Dahl hypertension-sensitive (SS/Jr) strains. Phenylephrine and sodium nitroprusside were administered through jugular catheters in graded doses to elicit a range of pressor and depressor responses, for which corresponding reflex decreases and increases in heart rate were recorded. To assess the relative contributions of sympathetic and parasympathetic branches of autonomic control to baroreflex functioning, atropine methyl nitrate and atenolol were administered to establish vagal blockade, and cardiac sympathetic blockade, respectively. Assuming a sigmoidal relationship between mean arterial pressure and heart rate changes, our results indicated that SS/Jr rats exhibited elevated blood pressure set-points for baroreceptor activation and roughly similar baroreflex sensitivity compared with SR/Jr rats. In contrast, using linear regression analyses, our results indicated that SS/Jr rats had significant reductions in baroreceptor sensitivity when arterial pressure was increased by phenylephrine. Baroreceptor sensitivity was similar between rats of the two strains when arterial pressure was reduced by administration of nitroprusside. Atropin...Continue Reading

Citations

Nov 26, 2010·Cardiovascular Diabetology·Aiji BokuHitoshi Niwa
Jul 6, 2006·Clinical and Experimental Hypertension : CHE·Etain Tansey, Christopher Bell
Oct 16, 2004·American Journal of Hypertension·Hélène GirouardJacques de Champlain
Dec 1, 2001·Clinical and Experimental Hypertension : CHE·M A BayorhM Thierry-Palmer
Feb 25, 2003·Clinical and Experimental Hypertension : CHE·D EatmanM A Bayorh

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