Baroreflex dysfunction and augmented sympathetic nerve responses during mental stress in veterans with post-traumatic stress disorder.

The Journal of Physiology
Jeanie ParkBarbara O Rothbaum

Abstract

Patients with post-traumatic stress disorder (PTSD) are at a significantly higher risk of developing hypertension and cardiovascular disease. The mechanisms underlying this increased risk are not known. Studies have suggested that PTSD patients have an overactive sympathetic nervous system (SNS) that could contribute to cardiovascular risk; however, sympathetic function has not previously been rigorously evaluated in PTSD patients. Using direct measurements of sympathetic nerve activity and pharmacological manipulation of blood pressure, we show that veterans with PTSD have augmented SNS and haemodynamic reactivity during both combat-related and non-combat related mental stress, impaired sympathetic and cardiovagal baroreflex sensitivity, and increased inflammation. Identifying the mechanisms contributing to increased cardiovascular (CV) risk in PTSD will pave the way for developing interventions to improve sympathetic function and reduce CV risk in these patients. Post-traumatic stress disorder (PTSD) is associated with increased cardiovascular (CV) risk. We tested the hypothesis that PTSD patients have augmented sympathetic nervous system (SNS) and haemodynamic reactivity during mental stress, as well as impaired arterial bar...Continue Reading

Associated Clinical Trials

References

Oct 1, 1979·Physiological Reviews·A B VallboB G Wallin
Jan 1, 1988·Annual Review of Physiology·B G Wallin, J Fagius
Jan 1, 1972·Acta Physiologica Scandinavica·W DeliusB G Wallin
Jan 1, 1972·Acta Physiologica Scandinavica·W DeliusB G Wallin
May 1, 1984·Hypertension·D L WoodA Schirger
Aug 1, 1996·Behaviour Research and Therapy·E B BlanchardC A Forneris
May 18, 1999·The American Journal of Physiology·L RudasD L Eckberg
Jun 5, 2001·Depression and Anxiety·F W WeathersJ R Davidson
Jul 19, 2001·Annals of the New York Academy of Sciences·M W ChapleauF M Abboud
Aug 4, 2001·Psychosomatic Medicine·T C Buckley, D G Kaloupek
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jian CuiCraig G Crandall
Sep 11, 2002·Circulation·Frank A DinennoMichael J Joyner
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Cauveh EramiJames E Faber
Nov 25, 2003·Obesity Research·Fátima H S KuniyoshiCarlos E Negrão
Jul 2, 2004·The New England Journal of Medicine·Charles W HogeRobert L Koffman
Feb 12, 2005·The Journal of Physiology·Jason R CarterChester A Ray
Aug 12, 2006·Journal of Psychiatric Research·Roland von KänelUlrich Schnyder
Aug 15, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tadaaki ManoShinobu Toma
Jan 1, 2008·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Egle Corrado, Salvatore Novo
Jan 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jason R Carter, Chester A Ray
Feb 13, 2009·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Laura D KubzanskyWilliam W Eaton
Aug 6, 2009·JAMA : the Journal of the American Medical Association·Beth E CohenKaren H Seal
Oct 20, 2010·Annals of the New York Academy of Sciences·Albert Skip RizzoRob McLay
Oct 20, 2010·Annals of the New York Academy of Sciences·Barbara O RothbaumJoAnn Difede
Oct 26, 2010·European Heart Journal·Jolanta WalczewskaTomasz Grodzicki
Nov 26, 2010·Circulation·Philip GreenlandUNKNOWN American College of Cardiology Foundation/American Heart Asscoiation Tasl Force on Practice Guidelines

❮ Previous
Next ❯

Citations

Jun 7, 2017·The Journal of Physiology·Jason R Carter
Jul 18, 2017·The Journal of Physiology·Luiz Eduardo Virgilio Silva, Pedro Lourenço Katayama
Apr 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Ida T FonkoueJeanie Park
Oct 20, 2018·Nature Reviews. Nephrology·Alan Kim Johnson, Baojian Xue
Oct 12, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ida T FonkoueJeanie Park
Mar 16, 2019·Social Work in Health Care·James D WhitworthTracy Wharton
Apr 18, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michinari HiedaQi Fu
Dec 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rachel C DrewJeanie Park
May 10, 2020·European Heart Journal·Jiahao DuanLing Yang
Sep 24, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cortnie L HartwigJeanie Park
Aug 28, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ida T FonkoueJeanie Park
Apr 4, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jeung-Ki YooQi Fu
May 30, 2019·Frontiers in Behavioral Neuroscience·Cassandra M MoshfeghAdam J Case
Mar 7, 2020·Science·Naoya KataokaKazuhiro Nakamura
Nov 30, 2018·Frontiers in Behavioral Neuroscience·Adam P SwierczPaul J Marvar
Feb 18, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kenneth M MaddenGraydon S Meneilly
Dec 6, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuya Kishi
Sep 11, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·You Kyoung ShinGeun Hee Seol
Oct 7, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ida T FonkoueJeanie Park
Aug 31, 2019·Neurobiology of Stress·Nuria DaviuAnna Beyeler
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Seth W HolwerdaPaul J Fadel
Feb 9, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Antonia V SeligowskiKerry J Ressler
Dec 31, 2020·International Journal of Molecular Sciences·Joyce BernardiAdemuyiwa S Aromolaran
Nov 22, 2020·Journal of Bodywork and Movement Therapies·Mostafa SarabzadehMasoumeh Helalizadeh
Mar 13, 2021·Trends in Cardiovascular Medicine·Amit J ShahViola Vaccarino
Jun 24, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Mikołaj Tytus Szulczewski
Jun 3, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer B WeggenRyan S Garten
Aug 12, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takuto HamaokaJian Cui
Nov 4, 2021·Nature Reviews. Neuroscience·Kazuhiro NakamuraNaoya Kataoka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.