Baroreflex dysfunction in chronic kidney disease

World Journal of Nephrology
Manpreet KaurKishore Kumar Deepak

Abstract

Chronic kidney disease (CKD) patients have high cardiovascular mortality and morbidity. The presence of traditional and CKD related risk factors results in exaggerated vascular calcification in these patients. Vascular calcification is associated with reduced large arterial compliance and thus impaired baroreflex sensitivity (BRS) resulting in augmented blood pressure (BP) variability and hampered BP regulation. Baroreflex plays a vital role in short term regulation of BP. This review discusses the normal baroreflex physiology, methods to assess baroreflex function, its determinants along with the prognostic significance of assessing BRS in CKD patients, available literature on BRS in CKD patients and the probable patho-physiology of baroreflex dysfunction in CKD.

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Citations

May 2, 2019·Journal of the American Society of Nephrology : JASN·Luca ZanoliPierre Boutouyrie
May 1, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·J C LaursenP Rossing
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