Baroreflex mechanisms in Irritable Bowel Syndrome: Part I. Traditional indices

Physiology & Behavior
Dmitry M DavydovDavid Shapiro

Abstract

This study was conducted to present evidence of differences in autonomic regulation of cardiovascular activity and its role in the severity of specific (disease-related) and non-specific (negative affect and chronic pain-related) symptoms in individuals with Irritable Bowel Syndrome (IBS). Seventy-eight female patients with IBS and 27 healthy women age 18-62 years were assessed for IBS symptoms, negative affect, and baroreceptor sensitivity (BRS), blood pressure (BP), heart rate, and heart rate variability (HRV) at rest. Direct and indirect regression effects were examined with application of the bootstrap procedure to validate findings. IBS was reliably related to lower resting BRS, higher BP, and higher negative affect compared to healthy controls. Longer disease duration (chronicity) was related to BRS decrease coupled with systolic BP increase (95% CIs=-0.14 to -0.01). Three autonomic mechanisms associated with BRS decrease were found to further regulate severity of IBS symptoms. Lower BRS was related to higher IBS severity in general if the effect was transferred through the decrease of low frequency power of HRV (e.g., 95% CIs=-0.039 to -0.001 for abdominal pain severity). However, lower BRS was related to lower IBS sever...Continue Reading

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Citations

Dec 3, 2016·Biological Psychology·Dmitry M Davydov, Róża Czabak-Garbacz
Nov 10, 2017·Pain·Stephen BruehlCraig A Smith
Aug 21, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Dmitry M DavydovBruce Naliboff
Jan 16, 2020·Sensors·David Naranjo-HernándezLaura M Roa
Feb 1, 2020·Journal of Hypertension·Dmitry M Davydov
Aug 24, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D M DavydovD Shapiro
Oct 30, 2020·The American Journal of Clinical Hypnosis·Louis F Damis, M Skyler Hamilton
Oct 15, 2021·Scientific Reports·Dmitry M DavydovGustavo A Reyes Del Paso

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