Barosensitive neurons in the rat tractus solitarius and paratrigeminal nucleus: a new model for medullary, cardiovascular reflex regulation

Canadian Journal of Physiology and Pharmacology
Antonio Balan JúniorC J Lindsey

Abstract

The nucleus of the solitary tract (NTS), a termination site for primary afferent fibers from baroreceptors and other peripheral cardiovascular receptors, contains blood pressure-sensitive neurons, some of which have rhythmic activity locked to the cardiac cycle, making them key components of the central pathway for cardiovascular regulation. The paratrigeminal nucleus (Pa5), a small collection of medullary neurons in the dorsal lateral spinal trigeminal tract, like the NTS, receives primary somatosensory inputs of glossopharyngeal, vagal, and other nerves. Recent studies show that the Pa5 has efferent connections to the rostroventrolateral reticular nucleus (RVL), NTS, and ambiguous nucleus, suggesting that its structure may play a role in the baroreceptor reflex modulation. In the present study, simultaneous recording from multiple single neurons in freely behaving rats challenged with i.v. phenylephrine administration, showed that 83% of NTS units and 72% of Pa5 units were baroreceptor sensitive. Whereas most of the baroreceptor-sensitive NTS and Pa5 neurons (86 and 61%, respectively) increased firing rate during the ascending phase of the pressor response, about 16% of Pa5 and NTS baroreceptor-sensitive neurons had a decreas...Continue Reading

References

Aug 1, 1978·Journal of Neurocytology·V Chan-Palay
Jun 1, 1991·The Journal of Comparative Neurology·W M Panneton
Jan 15, 1986·The Journal of Comparative Neurology·Y ShigenagaM Hosoi
Feb 1, 1984·The Journal of Comparative Neurology·R B Hamilton, R Norgren
Apr 10, 1983·The Journal of Comparative Neurology·N MizunoM Kudo
May 1, 1981·Clinical and Experimental Pharmacology & Physiology·R A Dampney
Oct 1, 1995·The American Journal of Physiology·X Zha, G H Morrison
Nov 1, 1993·The American Journal of Physiology·M J RogersB Horowitz
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·R A DampneyJ W Polson
Jun 1, 1996·Brain : a Journal of Neurology·J W ThorpeD H Miller
Jul 1, 1997·The Journal of Physiology·C J LindseyR C Lapa
Oct 7, 1997·Clinical and Experimental Pharmacology & Physiology·K M SpyerT Thomas
Mar 10, 2000·Brain Research Bulletin·S A AicherD J Reis
Apr 25, 2000·Brain : a Journal of Neurology·M G Spillantini, M Goedert
Jul 30, 2002·Autonomic Neuroscience : Basic & Clinical·Yun-Guo YuCharles J Lindsey
May 14, 2003·Autonomic Neuroscience : Basic & Clinical·Yun-Guo Yu, Charles Julian Lindsey
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·Cristofer Andre CaousCharles Julian Lindsey

❮ Previous
Next ❯

Citations

May 24, 2008·Acta Physiologica·J F ArgachaP van de Borne
Feb 3, 2016·Brain Research·John Ciriello, Monica M Caverson
Jul 20, 2010·Autonomic Neuroscience : Basic & Clinical·Ariadiny Lima CaetanoHudson Sousa Buck
Feb 4, 2009·Autonomic Neuroscience : Basic & Clinical·L O Sousa, Charles Julian Lindsey
Jan 31, 2009·Autonomic Neuroscience : Basic & Clinical·L O Sousa, Charles Julian Lindsey
Jul 2, 2015·The Journal of Comparative Neurology·Lama Bou FarahSimon McMullan
May 31, 2008·Autonomic Neuroscience : Basic & Clinical·Cristofer André CaousCharles Julian Lindsey
Jun 3, 2008·Autonomic Neuroscience : Basic & Clinical·Olavo Egídio AliotoCristofer André Caous
Apr 25, 2006·The European Journal of Neuroscience·Beverly A S ReyesElisabeth J Van Bockstaele
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Susan K Wood, James H Woods
May 27, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhi-Ling GuoLiang-Wu Fu
Jun 10, 2016·Physiological Reviews·Stuart B Mazzone, Bradley J Undem
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·Cristofer Andre CaousCharles Julian Lindsey
Sep 20, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Phoebe A StapletonTimothy R Nurkiewicz
Aug 18, 2018·Brain Structure & Function·Alexandria K DriessenStuart B Mazzone
Oct 27, 2017·Frontiers in Neurology·W Michael PannetonQi Gan
Sep 27, 2019·Frontiers in Physiology·Alexandria K Driessen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.