Barrel Jellyfish (Rhizostoma pulmo ) as Source of Antioxidant Peptides

Marine Drugs
Stefania De DomenicoAntonella Leone

Abstract

The jellyfish Rhizostoma pulmo, Macrì 1778 (Cnidaria, Rhizostomae) undergoes recurrent outbreaks in the Mediterranean coastal waters, with large biomass populations representing a nuisance or damage for marine and maritime activities. A preliminary overview of the antioxidant activity (AA) of R. pulmo proteinaceous compounds is provided here based on the extraction and characterization of both soluble and insoluble membrane-fractioned proteins, the latter digested by sequential enzymatic hydrolyses with pepsin and collagenases. All jellyfish proteins showed significant AA, with low molecular weight (MW) proteins correlated with greater antioxidant activity. In particular, collagenase-hydrolysed collagen resulted in peptides with MW lower than 3 kDa, ranging 3⁻10 kDa or 10⁻30 kDa, with AA inversely proportional to MW. No cytotoxic effect was detected on cultured human keratinocytes (HEKa) in a range of protein concentration 0.05⁻20 μg/mL for all tested protein fractions except for soluble proteins higher than 30 kDa, likely containing the jellyfish venom compounds. Furthermore, hydrolyzed jellyfish collagen peptides showed a significantly higher AA and provided a greater protective effect against oxidative stress in HEKa than th...Continue Reading

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Citations

Oct 28, 2019·Marine Drugs·Louise MerquiolIsabella D'Ambra
Feb 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federica AngilèFrancesco Paolo Fanizzi
Jun 4, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Luca SalvatoreAlessandro Sannino
Sep 10, 2021·Frontiers in Nutrition·Gianluca BleveAntonella Leone
Jan 13, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sonali JanaSamit Kumar Nandi

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Methods Mentioned

BETA
membrane filtration
gel filtration
zymography
Electrophoresis
Protein Assay
Assay

Software Mentioned

Graphpad Prism

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