Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Melis InanMichael C Crair

Abstract

The cellular and molecular mechanisms mediating the activity-dependent development of brain circuitry are still incompletely understood. Here, we examine the role of cAMP-dependent protein kinase [protein kinase A (PKA)] signaling in cortical development and plasticity, focusing on its role in thalamocortical synapse and barrel map development. We provide direct evidence that PKA activity mediates barrel map formation using knock-out mice that lack type IIbeta regulatory subunits of PKA (PKARIIbeta). We show that PKARIIbeta-mediated PKA function is required for proper dendritogenesis and the organization of cortical layer IV neurons into barrels, but not for the development and plasticity of thalamocortical afferent clustering into a barrel pattern. We localize PKARIIbeta function to postsynaptic processes in barrel cortex and show that postsynaptic PKA targets, but not presynaptic PKA targets, have decreased phosphorylation in pkar2b knock-out (PKARIIbeta(-/-)) mice. We also show that long-term potentiation at TC synapses and the associated developmental increase in AMPA receptor function at these synapses, which normally occurs as barrels form, is absent in PKARIIbeta(-/-) mice. Together, these experiments support an activity...Continue Reading

Citations

Nov 17, 2009·Cerebral Cortex·Emily A KellyAnia K Majewska
Feb 14, 2012·Human Molecular Genetics·Sally M TillPeter C Kind
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas Narboux-NêmePatricia Gaspar
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takuji IwasatoMichael C Crair
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos J Ballester-RosadoHui-Chen Lu
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lasani S WijetungePeter C Kind
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia Brill, John R Huguenard
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark F JacquinZhou-Feng Chen
Feb 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark E LushLuis F Parada
Jul 11, 2008·The Journal of Comparative Neurology·Carlomagno Pacheco BahiaAntonio Pereira
Mar 13, 2014·Cerebral Cortex·Alex Crocker-BuqueMichael I Daw
Mar 3, 2007·Molecular and Cellular Neurosciences·Michael I DawJohn T R Isaac
Jan 19, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Melis Inan, Michael C Crair
Apr 17, 2017·Neuroscience·Francisco J MartiniGuillermina López-Bendito
May 23, 2008·The Journal of Comparative Neurology·Elizabeth A Kichula, George W Huntley
Jun 13, 2009·The European Journal of Neuroscience·Wei-Chi SheHui-Chen Lu
May 4, 2011·Annals of the New York Academy of Sciences·Hong Li, Michael C Crair
May 23, 2012·The European Journal of Neuroscience·Reha S Erzurumlu, Patricia Gaspar
Jun 22, 2007·Journal of Neurophysiology·Michael J AlbrightMichael C Crair
Nov 17, 2009·Biochemical Society Transactions·C Geoffrey LauR Suzanne Zukin
Jun 27, 2019·Journal of Cellular Biochemistry·Xianjun SunJingcheng Dong
Jul 22, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Adel MakladLaura A Hansen
Oct 9, 2020·Development, Growth & Differentiation·Takuji Iwasato
Aug 3, 2021·Journal of Neuroscience Methods·Crystian I MassengillHaining Zhong
May 19, 2009·Neuron·Haining ZhongKarel Svoboda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ruth F WatsonPaul E Neumann
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Takuji IwasatoMichael C Crair
Science's STKE : Signal Transduction Knowledge Environment
S Impey, R H Goodman
© 2022 Meta ULC. All rights reserved