Barrett Esophagus: Evolving Concepts in Diagnosis and Neoplastic Progression

Surgical Pathology Clinics
Mikhail Lisovsky, Amitabh Srivastava

Abstract

Surgical pathologists need to answer 2 questions when evaluating biopsies from the distal esophagus or gastroesophageal junction in patients with a history of gastroesophageal reflux disease: Are the findings consistent with Barrett esophagus? and Is there any evidence of dysplasia? Pathologists should be well informed about the controversy around the definition of Barrett esophagus and the common pitfalls that lead to a false-positive diagnosis of Barrett esophagus or Barrett esophagus-associated dysplasia. A concise description of distinct morphologic types of dysplasia in Barrett esophagus and a summary of recent data on the natural history of BE are provided in this review.

References

Jul 21, 2004·Cancer Cell·Thomas G Paulson, Brian J Reid
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Aug 13, 2008·Journal of the National Cancer Institute·Linda Morris BrownWong-Ho Chow
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Jun 18, 2011·Gastroenterology·Nicholas J ShaheenCharles J Lightdale
Oct 1, 2011·The American Journal of Surgical Pathology·Parakrama ChandrasomaTom DeMeester

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