Barrett's esophagus: a retrospective analysis of 13 years surveillance

Journal of Gastroenterology and Hepatology
Victoria Switzer-TaylorMichael Schultz

Abstract

The incidence of esophageal adenocarcinoma has increased significantly. Barrett's esophagus (BE), a known precursor, has a high prevalence but only few patients with this condition progress to malignancy--surveillance and screening programs are controversial and lack proven efficacy. This retrospective analysis reviews the 13-year outcome for patients entered into a surveillance program. Data from patients with histologically proven Barrett's esophagus (1992-2003) that participated in a surveillance program were identified and analyzed retrospectively until 2005. 404/536 patients had Barrett's esophagus confirmed histologically of which 212 (53%) were followed in a surveillance program (mean 3.95 years per patient). This resulted in 749 gastroscopies (3.5/patient). Histologically, Barrett's mucosa was seen in 54%, low-grade dysplasia in 18%, ulcerations in 9%, high-grade dysplasia in 2%. No metaplasia was seen in 13%, no biopsy was obtained in 3%. Nine of 212 patients (4.3%) under surveillance developed esophageal cancer; two presented with symptoms, requiring gastroscopy outside the surveillance program (1/2 was operated successfully, one had advanced disease). In seven asymptomatic patients, cancer was detected on routine end...Continue Reading

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Mar 31, 2009·Investigational New Drugs·Judith Meza-JuncoMichael B Sawyer
Oct 20, 2011·The Nurse Practitioner·Summer Cross
Oct 16, 2008·Journal of Gastroenterology and Hepatology·Lybus Hillman
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Oct 31, 2019·World Journal of Gastrointestinal Oncology·Osman AhmedJeffrey H Lee
Oct 2, 2013·Gastrointestinal Endoscopy·Louisa G GordonDavid I Watson

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