Barrett's Esophagus after Bimodality Therapy in Patients with Esophageal Adenocarcinoma

Oncology
Fatemeh G AmlashiJaffer A Ajani

Abstract

Barrett's esophagus (BE) may be present in patients with esophageal adenocarcinoma (EAC) after bimodality therapy (BMT). There is no specific guidance for follow-up of these patients with regard to the presence of BE or dysplasia. In this study, we assessed the outcomes of patients who, after BMT, had BE and those who did not. Patients with EAC who had BMT were identified and analyzed retrospectively in two groups, with and without BE. We compared patient characteristics and outcome variables (local, distant, and no recurrence). Of 228 patients with EAC, 68 (29.8%) had BE before BMT. Ninety-eight (42.9%) had BE after BMT, and endoscopic intervention was done in 11 (11.2%). With a median follow-up of 37 months, the presence of post-BMT BE was not significantly associated with overall survival (OS) and local recurrence-free survival (LRFS). Similarly, endoscopic intervention was not significantly associated with OS and LRFS. Fifty (73.5%) patients with BE before BMT had BE after BMT (p < 0.0001). The presence of BE after BMT was not associated with increased risk of local recurrence. The local recurrence rate was not influenced by endoscopic intervention. Prospective studies are warranted to generate guidance for intervention, if...Continue Reading

References

Apr 19, 2002·JAMA : the Journal of the American Medical Association·Nicholas Shaheen, David F Ransohoff
Apr 19, 2002·JAMA : the Journal of the American Medical Association·Nicholas Shaheen, David F Ransohoff
Sep 3, 2003·Nature Reviews. Cancer·Christopher P Wild, Laura J Hardie
Aug 28, 2004·The American Journal of Gastroenterology·Allan P WestonMatthew Hall
Sep 7, 2007·Lifetime Data Analysis·Jon A Wellner
Sep 29, 2007·Alimentary Pharmacology & Therapeutics·T ThomasR J Robinson
Nov 22, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P CenJ A Ajani
May 29, 2009·The New England Journal of Medicine·Nicholas J ShaheenCharles J Lightdale
Oct 24, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marjolein SikkemaErnst J Kuipers
Dec 17, 2009·Gastrointestinal Endoscopy·James S BarthelCraig W Stevens
Dec 1, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sachin WaniPrateek Sharma
May 18, 2011·The American Journal of Gastroenterology·M SikkemaP D Siersema
Jun 18, 2011·Gastroenterology·Nicholas J ShaheenCharles J Lightdale
Jun 18, 2011·Journal of the National Cancer Institute·Shivaram BhatLiam J Murray
Oct 15, 2011·The New England Journal of Medicine·Frederik Hvid-JensenPeter Funch-Jensen
Jul 10, 2012·Gastroenterology·Elizabeth L Bird-LiebermanRebecca C Fitzgerald
Jul 27, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J A AjaniS G Swisher
Oct 23, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuki SudoJaffer A Ajani
Oct 30, 2013·Gut·Rebecca C FitzgeraldUNKNOWN British Society of Gastroenterology
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vera OppedijkMaarten C C M Hulshof
Mar 29, 2014·JAMA : the Journal of the American Medical Association·K Nadine PhoaJacques J G H M Bergman
Sep 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuki SudoJaffer A Ajani
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Nov 4, 2015·The American Journal of Gastroenterology·Nicholas J ShaheenUNKNOWN American College of Gastroenterology
Jan 17, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sonja KroepChin Hur
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Caryn S Ross-InnesUNKNOWN BEST2 study group
Jan 25, 2018·Annals of the Royal College of Surgeons of England·P H PucherS J Mercer

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Related Papers

The American Journal of Gastroenterology
Pieter J F de JongePeter D Siersema
Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
Iu V Vasil'ev
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Cadman L LeggettPrasad G Iyer
© 2022 Meta ULC. All rights reserved