Barrett's esophagus is associated with a distinct oral microbiome

Clinical and Translational Gastroenterology
Erik J SniderJulian A Abrams

Abstract

The esophageal microbiome is composed of predominantly oral flora and is altered in reflux-related conditions including Barrett's esophagus (BE). Changes to the esophageal microbiome may be reflected in the oral cavity. Assessing the oral microbiome thus represents a potential non-invasive method to identify patients with BE. Patients with and without BE undergoing upper endoscopy were prospectively enrolled. Demographics, clinical data, medications, and dietary intake were assessed. 16S rRNA gene sequencing was performed on saliva samples collected prior to endoscopy. Taxonomic differences between groups were assessed via linear discriminant analysis effect size (LEfSe). Logit models were used to develop microbiome signatures to distinguish BE from non-BE, assessed by area under the receiver operating curve (AUROC). A total of 49 patients were enrolled (control = 17, BE = 32). There was no significant difference in alpha diversity comparing all BE patients vs. At the phylum level, the oral microbiome in BE patients had significantly increased relative abundance of Firmicutes (p = 0.005) and decreased Proteobacteria (p = 0.02). There were numerous taxonomic differences in the oral microbiome between BE and controls. A model inc...Continue Reading

Citations

Jul 13, 2019·Frontiers in Cellular and Infection Microbiology·Marco MascittiAndrea Santarelli
Jul 28, 2019·Current Gastroenterology Reports·Don C Codipilly, Prasad G Iyer
Dec 15, 2019·Scientific Reports·Qian WangYuan Li
May 1, 2020·International Journal of Oral Science·Jin XiaoSteven R Gill
Jul 6, 2019·Digestive Diseases and Sciences·Brittany L Baldwin-HunterJulian A Abrams
Aug 31, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Erik J SniderJulian A Abrams
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Qiaofei ZhaoBaoyong Wang
Jan 30, 2021·Clinical and Translational Gastroenterology·Medini K AnnavajhalaJulian A Abrams
Nov 17, 2020·Frontiers in Immunology·Muhammad IrfanJorge Frias-Lopez
Mar 13, 2021·Frontiers in Cellular and Infection Microbiology·Ikenna C OkerekeRichard B Pyles
May 25, 2021·World Journal of Gastroenterology : WJG·Steve M D'SouzaDavid A Johnson
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Methods Mentioned

BETA
PCR

Software Mentioned

phyloseq
Stata
FastTree
DESeq
DESeq2
USEARCH
mothur
LEfSe
Cladogram

Related Concepts

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Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.