Barrett's oesophagus: frequency and prediction of dysplasia and cancer

Best Practice & Research. Clinical Gastroenterology
Gary W Falk

Abstract

The incidence of oesophageal adenocarcinoma is continuing to increase at an alarming rate in the Western world today. Barrett's oesophagus is a clearly recognized risk factor for the development of oesophageal adenocarcinoma, but the overwhelming majority of patients with Barrett's oesophagus will never develop oesophageal cancer. A number of endoscopic, histologic and epidemiologic risk factors identify Barrett's oesophagus patients at increased risk for progression to high-grade dysplasia and oesophageal adenocarcinoma. Endoscopic factors include segment length, mucosal abnormalities as seemingly trivial as oesophagitis and the 12 to 6 o'clock hemisphere of the oesophagus. Both intestinal metaplasia and low grade dysplasia, the latter only if confirmed by a pathologist with expertise in Barrett's oesophagus pathologic interpretation are the histologic risk factors for progression. Epidemiologic risk factors include ageing, male gender, obesity, and smoking. Factors that may protect against the development of adenocarcinoma include a diet rich in fruits and vegetables, and the use of proton pump inhibitors, aspirin/NSAIDs and statins.

References

Dec 1, 1986·Journal of Clinical Gastroenterology·E L RogersR L Smith
Jul 1, 1985·Annals of Internal Medicine·D W CrabbG A Lehman
Mar 11, 1998·Journal of Clinical Gastroenterology·N ChalasaniJ P Waring
Jul 27, 1999·Gastroenterology·R Ouatu-LascarG Triadafilopoulos
Mar 14, 2000·Annals of Surgery·S R DeMeester, T R DeMeester
Aug 19, 2000·Paediatric and Perinatal Epidemiology·A Rolett, J L Kiely
Sep 18, 2003·Journal of the National Cancer Institute·Lawrence S EngelJoseph F Fraumeni
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joanna R OlliverChristopher P Wild
Nov 8, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gary W FalkDon M Wachsberger
Apr 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Prateek SharmaRichard E Sampliner
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amitabh ChakCharis Eng
Oct 31, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L D WangX S Feng
Jan 9, 2007·Alimentary Pharmacology & Therapeutics·M KerkhofUNKNOWN Cybar Study Group
Apr 5, 2007·Journal of the National Cancer Institute·Elisabeth I HeathUNKNOWN Chemoprevention for Barrett's Esophagus Trial Research Group
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Clive J KeltyRoger Ackroyd
Nov 13, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Theodoros RokkasGeorgios Margantinis
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X-F ZhangJ-H Zhang
Jan 29, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christian C AbnetArthur Schatzkin
Mar 12, 2008·World Journal of Gastroenterology : WJG·Srinivas-R PuliMainor-R Antillon
May 15, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A R A L RossiniJ P P Moraes-Filho
Jun 10, 2008·International Journal of Cancer. Journal International Du Cancer·Stephanie A Navarro SilveraJoseph F Fraumeni
Aug 13, 2008·Journal of the National Cancer Institute·Linda Morris BrownWong-Ho Chow
Feb 19, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L M BullH B El-Serag
Feb 25, 2009·Gastroenterology·Hashem B El-Serag, Jesper Lagergren
Mar 3, 2009·Gastroenterology·Nirmala PandeyaUNKNOWN Australian Cancer Study
Oct 24, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marjolein SikkemaErnst J Kuipers
Mar 5, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xiangqing SunAmitabh Chak
Apr 17, 2010·Digestive Diseases and Sciences·Dang M NguyenHashem B El-Serag
Jul 14, 2010·Nutrition Research Reviews·Ai KuboRubinder Kaur
Dec 18, 2010·The American Journal of Surgical Pathology·Dominique P CocoRobert D Odze

❮ Previous
Next ❯

Citations

Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gregoire F Le BrasClaudia D Andl
Mar 26, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Bhawna Gupta, Narinder Kumar
Jul 30, 2020·Obesity Surgery·L LallemandC Blanchard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.