PMID: 9443041Jan 27, 1998Paper

Barrett's oesophagus: microsatellite analysis provides evidence to support the proposed metaplasia-dysplasia-carcinoma sequence

Genes, Chromosomes & Cancer
C M GleesonS E Russell

Abstract

The development of adenocarcinoma in Barrett's oesophagus is proposed to occur via a stepwise progression recognised histologically as a metaplasia-dysplasia-carcinoma sequence. In order to identify chromosomal loci involved in the malignant transformation of Barrett's epithelium and the development of oesophageal adenocarcinoma, microsatellite analysis was carried out on 17 cases of Barrett's-associated oesophageal adenocarcinoma. Samples of premalignant Barrett's epithelium adjacent to adenocarcinoma were obtained from seven of these cases. Allelic imbalance was detected in > 45% of informative cases of oesophageal adenocarcinoma on chromosome arms 3q (65%), 4q (71%), 5q (59%), 6q (59%), 9p (50%), 9q (47%), 12p (47%), 12q (65%), 17p (76%), and 18q (75%). Allelic imbalance at 4q, 17p, and 18q was significantly higher than the upper 95% confidence interval for background allelic imbalance. Allelic imbalance was detected at several loci in the premalignant epithelium from five of the seven cases studied. These loci included several chromosomal arms that had demonstrated high levels of allelic imbalance in oesophageal adenocarcinoma, namely, 4q (one case), 5q (two cases), 9 (three cases), 12q (five cases), 17p (four cases), and 1...Continue Reading

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Citations

Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·C M GleesonJ M Sloan
Mar 1, 2012·Current Gastroenterology Reports·Licia PensabeneMichael Thomson
Feb 10, 2000·The American Journal of Pathology·A K WalchM Werner
Mar 16, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mona FahmyGary W Falk
Feb 27, 2001·Annals of Surgery·B P WijnhovenW N Dinjens
Aug 3, 2014·Gastroenterology Report·Arthi KumaravelMadhusudhan R Sanaka
Oct 13, 2006·Surgical Oncology Clinics of North America·Laura H Tang, David S Klimstra
Nov 22, 2005·Journal of Surgical Oncology·Linetta B KoppertWinand N M Dinjens
Apr 10, 2002·American Journal of Clinical Pathology·Taofeek OwonikokoMario Sarbia
Oct 22, 2002·Molecular Biology of the Cell·Mark C SurkaWilliam S Trimble
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A K WalchM Werner
Sep 3, 2009·The American Journal of Gastroenterology·Pieter J F de JongeErnst J Kuipers
Jul 30, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Thorsten WiechMartin Werner

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