Barrett's oesophagus with predominant intestinal metaplasia correlates with superficial cyclo-oxygenase-2 expression, increased proliferation and reduced apoptosis: changes that are partially reversed by non-steroidal anti-inflammatory drugs usage

Alimentary Pharmacology & Therapeutics
Yuji AmanoYoshikazu Kinoshita

Abstract

Cyclo-oxygenase-2 expression has been reported to play an important role in the metaplasia-dysplasia-carcinoma sequence in Barrett's oesophagus. However, the existence of cyclo-oxygenase-2 expressing cells in Barrett's epithelium is still uncertain. To identify the cells that express cyclo-oxygenase-2 protein and to investigate the relationship between cyclo-oxygenase-2 expression and mucin-phenotype of Barrett's epithelium. Sections from 466 biopsy samples of Barrett's epithelium from 358 non-medicated patients were immunohistochemically examined for the cyclo-oxygenase-2 expression, mucin-phenotype, cell proliferation and apoptosis. Cyclo-oxygenase-2 expression was detected in 71.0% of Barrett's epithelium biopsy samples. In Barrett's epithelium with the gastric predominant mucin-phenotype, cyclo-oxygenase-2 expression was mainly found in stromal and deep epithelial cells, whereas in intestinal predominant mucin-phenotype, it was mostly in superficial epithelial cell. A significant elevation of proliferating cell nuclear antigen index and suppression of apoptotic index was observed in Barrett's epithelium with superficial epithelial cyclo-oxygenase-2 expression. Neither such elevation of proliferating cell nuclear antigen ind...Continue Reading

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Citations

Jun 15, 2007·Journal of Gastroenterology and Hepatology·Yuji AmanoYoshikazu Kinoshita
Feb 22, 2008·Journal of Gastroenterology and Hepatology·Daisuke ChinukiYoshikazu Kinoshita
Jan 16, 2009·Journal of Gastroenterology and Hepatology·Nobuyuki MoriyamaYoshikazu Kinoshita
Dec 25, 2008·Journal of Gastroenterology·Koichi OkitaYoshikazu Kinoshita
Oct 25, 2006·Alimentary Pharmacology & Therapeutics·S MehtaM Rhodes
Apr 7, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yoshiko TakahashiYoshikazu Kinoshita
Jun 29, 2006·Scandinavian Journal of Gastroenterology·Yuji AmanoYoshikazu Kinoshita
Sep 29, 2011·Annals of the New York Academy of Sciences·George TriadafilopoulosValter Nilton Felix
Sep 30, 2020·Surgical Case Reports·Naoki KuwayamaYoshihiro Nabeya

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