Barrier dysfunction or drainage reduction: differentiating causes of CSF protein increase

Fluids and Barriers of the CNS
Mahdi AsgariVartan Kurtcuoglu

Abstract

Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies. Among multiple existing approaches to interpreting measured protein levels, the Reiber diagram is particularly robust with respect to physiologic inter-individual variability, as it uses multiple subject-specific anchoring values. Beyond reliable identification of abnormal protein levels, the Reiber diagram has the potential to elucidate their pathophysiologic origin. In particular, both reduction of CSF drainage from the cranio-spinal space as well as blood-CNS barrier dysfunction have been suggested ρas possible causes of increased concentration of blood-derived proteins. However, there is disagreement on which of the two is the true cause. We designed two computational models to investigate the mechanisms governing protein distribution in the spinal CSF. With a one-dimensional model, we evaluated the distribution of albumin and immunoglobulin G (IgG), accounting for protein transport rates across blood-CNS barriers, CSF dynamics (including both dispersion induced by CSF pulsations and advection by mean CSF flow) and CSF drainage. Dispersion coefficients were determined a priori by c...Continue Reading

References

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Dec 9, 2016·Scientific Reports·Mahdi AsgariVartan Kurtcuoglu

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Citations

Feb 3, 2018·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Aug 29, 2019·The Journal of Experimental Medicine·Qiaoli MaSteven T Proulx
Jun 12, 2020·Brain Sciences·Kimon RungeDominique Endres
May 16, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G V GavrilovD V Svistov
Oct 21, 2018·Fluids and Barriers of the CNS·Stephen B Hladky, Margery A Barrand
Dec 15, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hansotto Reiber
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ekram Ahmed ChowdhuryLuca Cucullo

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Software Mentioned

Matlab
OpenFOAM

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