Barrier mechanisms for neutrotransmitter monoamines in the choroid plexus

Acta Physiologica Scandinavica
M LindvallC Owman

Abstract

Studies were performed on choroid plexuses from mouse and rat. The plexus tissue, sympathectomized to avoid interference from adrenergic nerves, is able to accumulate L-DOPA as well as NA and 5-HT against a concentration gradient. Within the plexus tissue these compounds are metabolized by aromatic L-amino acid decarboxylase, MAO and COMT, whose activities were determined radiometrically. On the basis of this and the fate of systemically administered L-DOPA and DA studied by fluorescence histochemistry it is suggested that the epithelium of the choroid plexus provides not only a structural but also an enzymatic barrier for transmitter amines. The enzymatic barrier for amine precursors is considerably less sufficient at this blood-CSF interphase. The trapping of monoamines resembles the enzymatic barrier present in the endothelial cells and pericytes at the microvascular level of the blood-brain interphase.

References

Jan 1, 1976·Advances in Experimental Medicine and Biology·N H Bass, P Lundborg
Feb 1, 1975·The American Journal of Physiology·L A Wade, R Katzman
Nov 1, 1973·The Journal of Comparative Neurology·E Westergaard, M W Brightman
Mar 3, 1970·Brain Research·G J Dohrmann
Apr 1, 1971·Physiological Reviews·H F Cserr
Mar 1, 1971·The American Journal of Physiology·H F Cserr, D H VanDyke
Nov 1, 1965·Biochemical Pharmacology·Y Tochino, L S Schanker
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Mar 1, 1980·Acta Physiologica Scandinavica·J E Hardebo, C Owman
Nov 1, 1957·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G G GLENNERG W BROWN

❮ Previous
Next ❯

Citations

Jan 3, 2001·Microscopy Research and Technique·J F Ghersi-Egea, N Strazielle
Feb 1, 1982·Respiration Physiology·P Zapata, A Zuazo
May 1, 1992·Brain Research. Brain Research Reviews·C NilssonC Owman
Dec 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T KarhunenP Panula
Aug 7, 2013·Fluids and Barriers of the CNS·Ingrid KratzerJean-Francois Ghersi-Egea
Oct 1, 2011·Drug Development and Industrial Pharmacy·Shadabul HaqueSanjula Baboota
Dec 1, 1986·Journal of Neurochemistry·P J Conn, E Sanders-Bush
Dec 1, 1980·Journal of Neurochemistry·J E HardeboE Rosengren
Jun 25, 2013·Neuroscience and Biobehavioral Reviews·Niki AntypaAlessandro Serretti
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Lindvall, C Owman
Jan 26, 2018·Acta Neuropathologica·Jean-François Ghersi-EgeaBritta Engelhardt
Apr 1, 1981·Postgraduate Medical Journal·D T EvansB H Toh
May 5, 2021·The AAPS Journal·Austin Sun, Joanne Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.