Barriers to clinical trial enrollment of older adults with cancer: A qualitative study of the perceptions of community and academic oncologists.

Journal of Geriatric Oncology
Mina S SedrakWilliam Dale

Abstract

Oncologists can be one of the major barriers to older adult's participation in research. Multiple studies have described academic clinicians' concerns for not enrolling older adults onto trials. Although the majority of older adults receive their cancer care in the community, few studies have examined the unique challenges that community oncologists face and how they differ from oncologist-related barriers in academia. Semi-structured interviews were conducted by telephone or face-to-face with 44 medical oncologists (24 academic-based and 20 community-based) at City of Hope from March to June 2018. Interviews explored oncologists' perceptions of barriers to clinical trial enrollment of older adults with cancer. Data were analyzed using qualitative content analysis. Of the 44 participants, 36% were women and 68% were in practice for >10 years. Among the entire sample, stringent eligibility criteria (n = 20) and oncologist concerns for treatment toxicities (n = 15) were the most commonly cited barriers. Compared to academic oncologists, community oncologists more often cited patient attitudes, beliefs, and understanding (n = 9 vs. n = 2) and caregiver burden (n = 6 vs. n = 0). In contrast, compared to community oncologists, acade...Continue Reading

Citations

Oct 2, 2020·CA: a Cancer Journal for Clinicians·Mina S SedrakUNKNOWN Cancer and Aging Research Group (CARG)
May 28, 2020·Journal of Clinical Medicine·Jennifer LiuMina S Sedrak
Apr 1, 2021·Expert Review of Gastroenterology & Hepatology·Alessandro RizzoGiovanni Brandi
Apr 22, 2021·Journal of the National Cancer Institute·Dany HabrVassiliki A Papadimitrakopoulou
May 28, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie A FlannerySupriya G Mohile

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