Barriers to Horizontal Gene Transfer in Campylobacter jejuni

Advances in Applied Microbiology
Susan P Gardner, Jonathan W Olson

Abstract

Campylobacter jejuni is among the most frequent agent of foodborne gastroenteritis in the world, but its physiology and pathogenesis is less well understood than other bacterial enteric pathogens. This is due in part to the incompatibility of the molecular tools that have enabled advances in the characterization of other bacterial species. Most notably, the dearth of plasmid-based complementation, reporter assays, and plasmid-based unmarked mutagenesis procedures in many of the type strains has hindered research progress. The techniques themselves are not inadequate in Campylobacter species, but rather the barrier to genetic transfer of these genetic constructs from non-Campylobacter cloning stains such as Escherichia coli. Here, we review the modes of genetic transfer in C. jejuni and review the current state of research into the mechanism of each. Also reviewed are two systems (CRISPR-Cas and restriction modification) that are common to many strains of C. jejuni and are at least partly responsible for these barriers.

Citations

Jul 19, 2013·Critical Reviews in Microbiology·Mario Juhas
Jun 22, 2013·The Journal of Antimicrobial Chemotherapy·Alessandra PiccirilloMartina Giacomelli
Sep 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jessica M BeauchampVictor J DiRita
Oct 12, 2018·Foodborne Pathogens and Disease·James L Smith, Nereus W Gunther Iv
Jun 16, 2018·Genome Announcements·J C SacherW G Miller
Mar 14, 2019·Scientific Reports·Matthias Frederik EmeleAndreas Erich Zautner
Jul 29, 2017·Genome Announcements·Susan P GardnerJonathan W Olson
Apr 7, 2021·Infection and Immunity·Roshika RoshikaPaul Sumby
May 16, 2021·Applied and Environmental Microbiology·Luyao MaXiaonan Lu
Oct 15, 2021·Frontiers in Microbiology·Vanina Guernier-CambertTorey Looft

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.