Barriers to the Interpretation of Body Composition in Colorectal Cancer: A Review of the Methodological Inconsistency and Complexity of the CT-Defined Body Habitus

Annals of Surgical Oncology
Jessica J HopkinsMichael B Sawyer

Abstract

Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been identified as predictive of survival in colorectal cancer (CRC). We performed a systematic review of contemporary studies to characterize this association and highlight methodological inconsistencies. MEDLINE and PubMed were queried for articles published from January 2000 on, with populations of resectable CRC and with CT-measured body composition and survival data. The study quality was assessed by two independent reviewers using the Newcastle-Ottawa Scale. Twenty studies met inclusion criteria, with a total of 8895 patients. Only two of the studies scored as high quality and nine as moderate quality. The remaining nine studies scored as low quality. Ten studies considered sarcopenia and 12 considered visceral obesity (VO). Cutoff points to define sarcopenia, myosteatosis, and VO were identified by optimal stratification, quartiles, or median values. The prevalence of sarcopenia varied from 15 to 60%, which based on study population and cutoff value used. Sarcopenia was associated with worse overall and disease-free survival in eight of the included studies. Myosteatosis was consider...Continue Reading

References

Apr 9, 2008·Annals of Surgical Oncology·Hyeong-Gon MoonSang-Kyung Choi
Jun 22, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Peter D PengTimothy M Pawlik
Jul 14, 2011·Journal of Surgical Oncology·Nikiforos BallianGregory D Kennedy
Jan 17, 2012·The British Journal of Surgery·M G van VledderJ N M Ijzermans
Aug 18, 2012·Asia-Pacific Journal of Clinical Oncology·Naoto YamamotoToshio Imada
Oct 24, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Aaron S RicklesJohn R T Monson
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Jul 13, 2013·Journal of Surgical Oncology·Michael S SabelStewart C Wang
Aug 29, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hee-Won JungJee Hyun Kim
Dec 17, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Toine M LodewickCornelis H C Dejong
Jan 8, 2015·Annals of Surgical Oncology·Yuji MiyamotoHideo Baba
May 6, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Se Woo ParkKang Hong Lee
Jul 25, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kostan W ReisingerMartijn Poeze
Feb 16, 2016·International Journal of Colorectal Disease·B C BoerJ M Klaase
Mar 21, 2016·The British Journal of Surgery·G MalietzisJ T Jenkins
Aug 24, 2016·Journal of Korean Medical Science·Eun Kyung ChoeEon Chul Han
Aug 31, 2016·Journal of Cancer Research and Clinical Oncology·Dong-Dong HuangCheng-Le Zhuang
Sep 8, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth M Cespedes FelicianoBette J Caan
Jan 21, 2017·Journal of Surgical Oncology·Abdelhamed HaramMichael J Kerin
Apr 19, 2017·Clinical Physiology and Functional Imaging·Anne van der WerfJacqueline A E Langius
May 17, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bette J CaanCarla M Prado
May 18, 2017·Journal of Cachexia, Sarcopenia and Muscle·Iris J G RuttenToon Van Gorp
Jun 2, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Stephen T McSorleyDonald C McMillan
Jul 5, 2017·Journal of Cachexia, Sarcopenia and Muscle·Vickie E Baracos
Jul 27, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jeroen L A van VugtFrançois E J A Willemsen

❮ Previous
Next ❯

Citations

Sep 22, 2018·Current Opinion in Supportive and Palliative Care·Sami AntounEmilie Lanoy
Aug 2, 2018·Journal of Cachexia, Sarcopenia and Muscle·Elizabeth M Cespedes FelicianoMarina Mourtzakis
Mar 21, 2020·Clinical Physiology and Functional Imaging·Taiara Scopel PoltronieriGabriela Villaça Chaves
Aug 7, 2020·AJR. American Journal of Roentgenology·Robert D Boutin, Leon Lenchik
Jul 15, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·V RodriguesM Armengol
Mar 12, 2021·European Radiology Experimental·Pablo BorrelliLars Edenbrandt
Jun 16, 2021·The Journal of Surgical Research·Bianka Saravana-BawanRachel G Khadaroo
Nov 10, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Taiara Scopel PoltronieriGabriela Villaça Chaves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.