Barriers to the utilization of genetic testing and genetic counseling in patients with suspected hereditary breast and ovarian cancers

Proceedings
Alicia SwinkJoanne L Blum

Abstract

A heritable condition is the identified cause of cancer in 5% to 10% of women with breast cancer and in 25% of women with ovarian cancer. It is critical to identify patients at risk for inherited genetic mutations to implement risk-reducing screening and interventions; however, reports in the medical literature indicate that an alarming number of patients with inherited genetic mutations do not receive recommended genetic counseling, testing, or interventions. In order to improve outcomes for these high-risk patients, barriers to genetic testing and counseling must be identified. We analyzed approximately 200 patients seen at our institution with breast or ovarian cancer who met criteria of the National Comprehensive Cancer Network for genetic counseling and testing. Of these patients, almost 70% had appropriate genetic testing and counseling. Review of the remaining 30% revealed that the largest obstacle to receiving genetic testing and/or counseling was lack of referral from the treating oncologist. Of the patients diagnosed with a pathogenic heritable mutation, most underwent appropriate risk-reducing procedures and surveillance. Thus, the initial referral to genetic counseling is the most significant barrier for at-risk pat...Continue Reading

References

May 18, 2007·Journal of Genetic Counseling·Janice L BerlinerUNKNOWN Practice Issues Subcommittee of the National Society of Genetic Counselors' Familial Cancer Risk Counseling Special Interest
Jan 4, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Mary B DalySusan Darlow
Jan 20, 2018·Breast Cancer Research and Treatment·Holly J PedersonStephen R Grobmyer
Mar 13, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J KatzAllison W Kurian

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Citations

Aug 29, 2020·Expert Review of Molecular Diagnostics·Sonya ReidTuya Pal
Sep 18, 2020·Journal of the American Medical Informatics Association : JAMIA·Thomas H PayneFuki M Hisama
Sep 25, 2020·JCO Oncology Practice·Tahlia ScheinbergLisa G Horvath
Feb 26, 2021·Interactive Journal of Medical Research·Melissa RaspaSaira Naim Haque
May 12, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jennifer L YoungHolly K Tabor
Jul 2, 2021·Irish Journal of Medical Science·Jana K McHughTerri P McVeigh

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