Bartonella-associated endothelial proliferation depends on inhibition of apoptosis

Proceedings of the National Academy of Sciences of the United States of America
James E Kirby, Dawn M Nekorchuk

Abstract

Bartonella is a Gram-negative pathogen that is unique among bacteria in being able to induce angioproliferative lesions. Cultured human endothelial cells have provided an in vitro system in which to study the basis of angioproliferation. Previous studies have attributed the organism's ability to induce angioproliferative lesions to direct mitotic stimulation of endothelial cells by these bacteria. Here we show that Bartonella inhibits apoptosis of endothelial cells in vitro, and that its ability to stimulate proliferation of endothelial cells depends to a large extent on its antiapoptotic activity. Bartonella suppresses both early and late events in apoptosis, namely caspase activation and DNA fragmentation, respectively. Its ability to inhibit death of endothelial cells after serum starvation can be recapitulated by media conditioned by bacteria, indicating that direct cell contact is not necessary. Among tested strains, the activity is produced only by Bartonella species that are significant human pathogens and are associated with angioproliferative lesions. We suggest that endothelial cells normally respond to infection by undergoing apoptosis and that Bartonella evolved the antiapoptotic activity to enhance survival of the ...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Sep 1, 1986·The American Journal of Surgical Pathology·J Arias-StellaJ Arias-Stella
Jan 1, 1996·Annual Review of Medicine·W Schwartzman
Feb 1, 1996·Analytical Biochemistry·O HohenwarterH Katinger
Jul 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M MaurinD Raoult
Mar 12, 1998·Infectious Disease Clinics of North America·D H Spach, J E Koehler
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·D R CliftonL A Sporn
Jan 23, 1999·The Journal of Clinical Investigation·D C Darland, P A D'Amore
Jul 27, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·M GräfeE Fleck
Nov 5, 1999·Annual Review of Microbiology·Y Weinrauch, A Zychlinsky
Nov 5, 1999·Annual Review of Microbiology·A RoulstonP E Branton
Mar 30, 2000·Infectious Disease Clinics of North America·C Maguiña, E Gotuzzo
Sep 9, 2000·The Journal of Biological Chemistry·O Steele-MortimerB B Finlay
Sep 16, 2000·Circulation Research·S Dimmeler, A M Zeiher

❮ Previous
Next ❯

Citations

Mar 28, 2012·Medical Microbiology and Immunology·Christiane BeerlageEdward B Breitschwerdt
Nov 28, 2012·Medical Microbiology and Immunology·Mrudula VaranatEdward B Breitschwerdt
Jul 10, 2003·The Journal of Infection·Whitney Greene, Guangming Zhong
Jun 29, 2002·Trends in Microbiology·Volkhard A J KempfIngo B Autenrieth
Mar 5, 2003·Current Opinion in Microbiology·Christoph Dehio
Nov 20, 2004·Nature Reviews. Microbiology·Jacques BatutDavid O'Callaghan
Aug 3, 2005·Nature Reviews. Microbiology·Christoph Dehio
Jul 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paola SalvatoreClaudio Napoli
May 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Arto T PulliainenChristoph Dehio
Nov 10, 2004·The Journal of Experimental Medicine·Tanja RiessVolkhard A J Kempf
Aug 9, 2003·DNA and Cell Biology·Sandra Resto-RuizBurt E Anderson
Dec 25, 2004·Cellular Microbiology·Volkhard A J KempfIngo B Autenrieth
Jan 11, 2012·Clinical Microbiology Reviews·Alexander Harms, Christoph Dehio
Aug 24, 2006·Infection and Immunity·Amy M McCordBurt E Anderson
Nov 24, 2004·Infection and Immunity·James E Kirby
Nov 28, 2007·Annual Review of Pathology·Gustavo Valbuena, David H Walker
Sep 15, 2010·BMC Medical Genomics·Valerio CostaClaudio Napoli
Jul 18, 2014·PLoS Neglected Tropical Diseases·Michael F MinnickRichard J Birtles
Nov 24, 2006·PLoS Pathogens·Michael C SchmidChristoph Dehio
Aug 8, 2009·Future Microbiology·Michael F Minnick, James M Battisti
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cecilia M AlsmarkSiv G E Andersson
Nov 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rita K LagunaRalph R Isberg
Aug 12, 2009·Medical Hypotheses·Eduardo TiconaMiguel G Madariaga
Mar 21, 2008·Trends in Microbiology·Christina S Faherty, Anthony T Maurelli
Jan 9, 2007·Current Opinion in Microbiology·Roger Vogelmann, Manuel R Amieva
Feb 17, 2006·Annals of the New York Academy of Sciences·Richard J Birtles
Feb 17, 2006·Annals of the New York Academy of Sciences·Laura S Smitherman, Michael F Minnick
Apr 9, 2010·Veterinary Dermatology·Julie A YagerEdward B Breitschwerdt
Aug 1, 2006·Thrombosis Research·Sanjeev K Sahni
May 20, 2004·International Journal of Medical Microbiology : IJMM·Siv G E Andersson, Volkhard A J Kempf
Jun 13, 2015·Journal of Medical Microbiology·Paola SalvatoreClaudio Napoli
Apr 17, 2010·The American Journal of Pathology·Lucius ChiaraviglioJames E Kirby
Dec 2, 2004·Acta Microbiologica Et Immunologica Hungarica·Nóra GyémántJ Molnár

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.