Bartonella species antibodies and DNA in cerebral spinal fluid of cats with central nervous system disease

Journal of Feline Medicine and Surgery
Karyn LeibovitzM R Lappin

Abstract

Bartonella species infection is associated with central nervous system (CNS) disease in some humans and cats but the diagnosis is difficult to confirm with blood or serum test results. In this retrospective study of 100 client-owned cats, serum and cerebral spinal fluid (CSF) were assayed for Bartonella species IgG antibodies and CSF was assayed for Bartonella species DNA. Bartonella species IgG antibodies were detected in serum of 36 cats, Bartonella species C-values>1 (suggesting antibody production by the CNS) were detected in CSF of 11 cats, and B henselae DNA was amplified from the CSF of 10 cats. While the clinical significance of these findings cannot be assessed without a control group, the development of neurological signs in some cats inoculated with B henselae and the results of this study warrant prospective evaluation of the association of Bartonella species with feline CNS disease.

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Citations

Jun 24, 2010·Journal of Feline Medicine and Surgery·Jane E SykesBruno B Chomel
Nov 9, 2011·Journal of Feline Medicine and Surgery·Danièlle A Gunn-Moore, Nicki Reed
Dec 8, 2010·Future Microbiology·Silpak Biswas, Jean-Marc Rolain
Dec 19, 2009·Veterinary Microbiology·Lynn Guptill
Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Edward B BreitschwerdtMichael R Lappin
Sep 3, 2015·JFMS Open Reports·Edward B BreitschwerdtNatalie A Cherry
Aug 25, 2012·Journal of Feline Medicine and Surgery·Bianca Stützer, Katrin Hartmann
Jul 3, 2013·Journal of Feline Medicine and Surgery·Maria Grazia PennisiMarian C Horzinek
Apr 25, 2019·The American Journal of Tropical Medicine and Hygiene·Juliana M RaimundoCristiane D Baldani

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
ELISA
nucleic acid amplification

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