Basal and insulin-regulated VLDL1 and VLDL2 kinetics in men with type 2 diabetes

Diabetologia
Rakel F JohansenS Nielsen

Abstract

Hypertriacylglycerolaemia is a hallmark of diabetic dyslipidaemia with increased concentrations of triacylglycerol (TG)-rich VLDL1 particles. However, whether VLDL1 secretion or removal is abnormal in type 2 diabetes remains unclear. The aim of this study was to compare basal and insulin-mediated VLDL1- and VLDL2-TG kinetics in men with type 2 diabetes and healthy men using a novel direct VLDL1- and VLDL2-TG labelling method. Twelve men with type 2 diabetes and 12 healthy men matched for age and BMI were recruited. VLDL1- and VLDL2-TG turnover were measured during a 4 h basal period and a 3.5 h hyperinsulinaemic clamp period using a primed-constant infusion of ex vivo labelled VLDL1-TG and VLDL2-TG. Basal VLDL1-TG and VLDL2-TG secretion rates were similar in men with diabetes and healthy men. During hyperinsulinaemia, VLDL1-TG secretion rates were suppressed significantly in both groups, whereas no suppression of VLDL2-TG secretion rate was observed. VLDL1-TG to VLDL2-TG transfer rate was not significantly different from zero in both groups, while VLDL1-TG fatty acid oxidation rate was substantial, with a contribution to total energy expenditure of approximately 15% during postabsorptive conditions. VLDL1 and VLDL2 particle siz...Continue Reading

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Dec 13, 2006·Metabolism: Clinical and Experimental·Michael D Jensen, Søren Nielsen
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Citations

May 24, 2016·Current Opinion in Lipidology·Handrean SoranPaul N Durrington
Apr 25, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Safwaan AdamPaul N Durrington
Nov 15, 2017·Current Opinion in Lipidology·Esben Søndergaard, Søren Nielsen
May 1, 2018·Current Opinion in Lipidology·Sei HiguchiRebecca A Haeusler
Oct 2, 2017·Metabolism: Clinical and Experimental·Esben SøndergaardSøren Nielsen
Nov 30, 2016·Current Opinion in Lipidology·Elias BjörnsonJan Borén

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