Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression.

Translational Psychiatry
Wessel A van EedenErik J Giltay

Abstract

Multiple studies show an association between inflammatory markers and major depressive disorder (MDD). People with chronic low-grade inflammation may be at an increased risk of MDD, often in the form of sickness behaviors. We hypothesized that inflammation is predictive of the severity and the course of a subset of MDD symptoms, especially symptoms that overlap with sickness behavior, such as anhedonia, anorexia, low concentration, low energy, loss of libido, psychomotor slowness, irritability, and malaise. We tested the association between basal and lipopolysaccharide (LPS)-induced inflammatory markers with individual MDD symptoms (measured using the Inventory of Depressive Symptomatology Self-Report) over a period of up to 9 years using multivariate-adjusted mixed models in 1147-2872 Netherlands Study of Depression and Anxiety (NESDA) participants. At baseline, participants were on average 42.2 years old, 66.5% were women and 53.9% had a current mood or anxiety disorder. We found that basal and LPS-stimulated inflammatory markers were more strongly associated with sickness behavior symptoms at up to 9-year follow-up compared with non-sickness behavior symptoms of depression. However, we also found significant associations wit...Continue Reading

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Citations

Sep 29, 2020·The British Journal of Psychiatry : the Journal of Mental Science·Derek K TracySukhwinder S Shergill
Dec 9, 2020·Current Psychiatry Reports·Robert D LevitanStephen G Matthews
Dec 9, 2020·International Journal of Molecular Sciences·Olga V AverinaVladimir P Chekhonin
Feb 8, 2021·Journal of Affective Disorders·Christiaan H VinkersBrenda W J H Penninx
Aug 14, 2021·Frontiers in Psychiatry·Riccardo De GiorgiCatherine J Harmer

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Methods Mentioned

BETA
blood draw

Software Mentioned

NESDA

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