Basal and post-ischemic vascular compliance in children/adolescents born small for gestational age.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Mirella StrambiAurelio Vittoria

Abstract

Intrauterine growth restriction plays a powerful role in influencing later susceptibility to certain chronic diseases, such as hypertension. Endothelial dysfunction and arterial stiffness are early events in the development of cardiovascular diseases (CVDs). We have studied vascular compliance in small for gestational age (SGA) children/adolescents in comparison with that in appropriate for gestational age (AGA) subjects. We monitored blood pressure, vascular resistance and compliance in 82 children-adolescents (52 SGA, 30 AGA), by means of pulse wave analysis (CR 2000 HDI) at the radial level, before and after 3 min of ischemic stress at the brachial level. In the children/adolescents born SGA we found a significant increase in systolic and diastolic blood pressure and vascular resistance in the basal condition; the large and small vessels were stiffer. After ischemia we observed an increased vascular response in the SGA children/adolescents: there was a great diminution of systolic and diastolic blood pressure and a larger increase of the elasticity of the conduit and resistance vessels. These data show that the SGA group presented some early signs of arterial wall functional disorders. More pediatric data are needed for the ...Continue Reading

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Citations

May 23, 2014·Cardiovascular Journal of Africa·Agata ZamecznikJerzy Stańczyk
Apr 11, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E MenghettiA Rosano
Aug 24, 2018·The Journal of Clinical Endocrinology and Metabolism·Wesley Jim GoedegebuureAnita Hokken-Koelega
Feb 19, 2016·Physiological Reviews·Jude S MortonSandra T Davidge
Mar 30, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Antonina OrlandoSimonetta Genovesi
Jun 5, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Simonetta GenovesiGianfranco Parati

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Methods Mentioned

BETA
SMA
SGA

Software Mentioned

SPSS
Pulse Wave CR - 2000
HDI

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