PMID: 8592633Sep 29, 1995Paper

Basal and scopolamine-evoked release of hippocampal acetylcholine following traumatic brain injury in rats

Neuroscience Letters
C E DixonR L Hayes

Abstract

This study employed in vivo microdialysis in awake, freely-moving Sprague-Dawley rats to examine acetylcholine (ACh) release in the dorsal hippocampus at 14 days following lateral controlled cortical impact. Extracellular levels of ACh were measured prior to and after an intraperitoneal administration of scopolamine (1 mg/kg), which evokes ACh release by blocking autoreceptors. At 14 days post injury there were no differences in basal ACh levels. However, injury produced a significant reduction in scopolamine-evoked ACh release. The data suggest that cholinergic neurotransmission remains chronically compromised, and thus may contribute to previously documented post traumatic spatial memory deficits.

References

Oct 1, 1991·Journal of Neuroscience Methods·C E DixonR L Hayes
Sep 1, 1989·The International Journal of Neuroscience·R BrandeisS Yehuda
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·C E DixonR L Hayes

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Citations

Apr 28, 2004·Neurotoxicity Research·F C AmadorC R Oliveira
Sep 19, 2003·Current Psychiatry Reports·David B Arciniegas
Dec 12, 2012·Translational Stroke Research·Coleen M Atkins
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·S M DeFordR J Hamm
Aug 15, 2013·Journal of Neural Transmission·Zhao-Liang Sun, Dong-Fu Feng
May 7, 2009·Neuroscience Letters·Coleen M AtkinsW Dalton Dietrich
Mar 20, 2004·Physical Medicine and Rehabilitation Clinics of North America·David B Arciniegas, Jeannie L Topkoff
Jun 23, 2015·Journal of Neurotrauma·Darrin J LeeKiarash Shahlaie
Nov 15, 2011·Neuroscience Letters·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Jan 23, 2020·International Journal of Molecular Sciences·Gokul KrishnaTheresa Currier Thomas

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