Basal and stimulated C-fos mRNA expression in the rat brain: effect of chronic dietary lithium

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
J C Miller, A A Mathé

Abstract

The mechanisms underlying the therapeutic efficacy of lithium in affective disorders are poorly understood; however, previous studies have established an influence of lithium on receptor-coupled and postreceptor signal transduction mechanisms, including the transcription factor c-fos. We investigated the effect of chronic lithium on basal, stress-, muscarinic-, and haloperidol-induced c-fos mRNA expression in various rat brain regions. Chronic lithium produced significant reductions in basal c-fos expression in the frontal cortex and hippocampus, confirming our previous report. Stress-induced c-fos was significantly attenuated in the frontal cortex, hippocampus, and pituitary, was increased in the occipital cortex, and unchanged in the hypothalamus by chronic lithium. Pilocarpine-induced c-fos was significantly reduced in the frontal cortex and hippocampus by chronic lithium, but was enhanced in the occipital cortex and hypothalamus. Haloperidol-induced c-fos was augmented in the striatum and pituitary, but reduced in the frontal cortex by chronic lithium treatment. In regions in which haloperidol did not induce fos expression in control animals, fos levels after haloperidol were reduced after chronic lithium. One week after di...Continue Reading

Citations

Jul 9, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z PangJ Li
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Galila Agam, Galit Shaltiel
Oct 14, 2006·The International Journal of Neuropsychopharmacology·Jeannette C MillerAleksander A Mathé
Dec 3, 1999·Journal of Neurochemistry·P YuanH K Manji

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