Basal and stress-induced differences in HPA axis, 5-HT responsiveness, and hippocampal cell proliferation in two mouse lines

Annals of the New York Academy of Sciences
Alexa H VeenemaE R de Kloet

Abstract

To characterize individual differences in neuroendocrine and neurochemical correlates of stress coping, two lines of wild house mice were studied. These mice are genetically selected for high and low aggression and show distinctly different behavioral strategies toward environmental stimuli. Long attack latency (LAL), low aggressive mice display a passive coping style, whereas short attack latency (SAL), high aggressive mice show an active coping style. It was hypothesized that this difference in behavioral coping style is associated with differences in stress system reactivity. This was tested by investigating the regulation of the hypothalamus-pituitary-adrenal (HPA) axis and the serotonin (5-HT) system and hippocampal cell proliferation rate in these mice under baseline and stress conditions. Baseline corticosterone output in LAL mice was found to be more sensitive to adrenocorticotropic hormone, but showed less day/night variation than in SAL mice. Furthermore, LAL mice showed lower hippocampal 5-HT(1A) receptor gene expression and function. Basal hippocampal cell proliferation rate was slightly lower in LAL than in SAL mice. Exposure to acute stress (forced swimming for 5 min) resulted in a hyper-reactive HPA response, a r...Continue Reading

References

Jul 1, 1992·Physiology & Behavior·D H OverstreetD S Janowsky
Oct 15, 1991·Experientia·R F BenusG A van Oortmerssen
Mar 1, 1981·Behavior Genetics·G A van Oortmerssen, T C Bakker
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C López-Rubalcava, I Lucki
Feb 22, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M F O'Neill, M W Conway
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·S M Korte
May 10, 2002·Journal of Neuroendocrinology·E van RielM Joëls
Oct 31, 2002·Behavior Genetics·Rainer Landgraf, Alexandra Wigger
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shanaz Tejani-ButtWilliam P Paré
Feb 18, 2003·Journal of Neuroendocrinology·A H VeenemaJ M Koolhaas
Dec 1, 1989·Behavioural Processes·R F BenusG A van Oortmerssen

❮ Previous
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Citations

Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Caroline M CoppensJaap M Koolhaas
Dec 8, 2009·Biological Reviews of the Cambridge Philosophical Society·Judy Stamps, Ton G G Groothuis
Jan 11, 2005·Critical Care Medicine·Eric K Noji
Jan 20, 2015·Physiology & Behavior·James L GoodsonMarcy A Kingsbury
Feb 7, 2012·Sleep Medicine·Jeanine KamphuisMarike Lancel
Jan 31, 2012·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Ida B JohansenOyvind Overli
Apr 13, 2010·Frontiers in Neuroendocrinology·J M KoolhaasB Buwalda
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Hymie AnismanJohn D H Stead
Mar 24, 2007·Frontiers in Neuroendocrinology·Alessandro Bartolomucci
Oct 24, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Regina WaltesChristine M Freitag
Sep 20, 2015·Behavioural Processes·Emma Michelle Pamela DelarueTasmin Lee Rymer
Jun 15, 2007·Journal of Neuroendocrinology·A H VeenemaP J Lucassen
Aug 8, 2006·Annals of the New York Academy of Sciences·Eric VermettenJ Douglas Bremner
Feb 12, 2005·Biological Psychiatry·Andrea PfennigElisabeth B Binder
Apr 11, 2006·Physiology & Behavior·J SchjoldenS Winberg
Feb 28, 2006·Biological Psychiatry·Mounira BanasrAnnie Daszuta
Jan 1, 2015·Neurobiology of Stress·Gretha J Boersma, Kellie L Tamashiro
Jun 15, 2012·Psychoneuroendocrinology·Marco Del Giudice
May 31, 2014·Behavioural Brain Research·Kathleen E MorrisonMatthew A Cooper
May 21, 2013·Physiology & Behavior·Winanda W UrsinusCornelis G van Reenen
Aug 12, 2014·Behavioural Brain Research·Stefano Puglisi-Allegra, Diego Andolina
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Victoria WobberPeter T Ellison
May 29, 2016·Neuroscience·Klaudia SzklarczykRyszard Przewlocki
Oct 5, 2007·Brain, Behavior and Evolution·Christina SørensenGöran E Nilsson
Oct 5, 2007·Brain, Behavior and Evolution·Jaap M KoolhaasKees van Reenen
Oct 5, 2007·Brain, Behavior and Evolution·Alexa H Veenema, Inga D Neumann
Jun 24, 2008·Journal of Immunotoxicology·Andrey A ZozulyaNatalia V Kost
Jun 21, 2020·The Journal of Experimental Biology·Małgorzata M LipowskaPaweł Koteja
Sep 25, 2019·The Journal of Experimental Biology·Małgorzata M LipowskaPaweł Koteja
Aug 7, 2020·Stress : the International Journal on the Biology of Stress·Damien HuzardFreddy Jeanneteau
Oct 13, 2020·Stress : the International Journal on the Biology of Stress·Eszter SiposDóra Zelena
Jan 8, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Barbora VobrubováDaniel Frynta
Aug 16, 2019·Frontiers in Neuroendocrinology·L S KalinichenkoC P Müller

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