PMID: 8951924Oct 1, 1996Paper

Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat

Pain
Q P Ma, C J Woolf

Abstract

Fos-immunoreactivity can readily be induced in spinal cord neurones by noxious, but to a much more limited extent, by innocuous peripheral stimuli. The present study has investigated whether low intensity stimuli and electrical stimulation of A beta afferents elicit greater c-fos expression during the behavioural sensory hypersensitivity generated by experimental peripheral inflammation. We have examined the time-course of c-fos expression after inflammation produced by either an intra-plantar injection of the irritant turpentine oil or of complete Freund's adjuvant (CFA). In the former case, a significant initial expression in all dorsal horn laminae was followed by a gradual decrease, whereas after CFA injection, an initial expression limited to the superficial laminae subsequently extended into the deep laminae, with a decrease at 24 h and an increase in labelling at later times. Low intensity touch stimuli repeated for 10 min, when applied at 24 h and 48 h after CFA injection, elicited a significant increase in the number of Fos-immunoreactive neurons in both the superficial and deep laminae of the dorsal horn compared to non-inflamed animals. Electrical stimulation of the sciatic nerve 24 h post-CFA injection, at a strengt...Continue Reading

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Citations

Mar 17, 2004·Brain Research·Jannon L FuchsHarris D Schwark
Jan 8, 2004·Brain Research Bulletin·Shi Ping ZhangHong Qi Zhang
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Sep 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ha-Neui KimByung-Tae Choi
Dec 24, 2015·The Journal of Pain : Official Journal of the American Pain Society·Joshua HavelinTamara King
Sep 4, 2015·CNS Neuroscience & Therapeutics·Douglas M Lopes, Stephen B McMahon
May 17, 2007·Diabetes/metabolism Research and Reviews·C Morgado, I Tavares
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Sep 1, 2002·Expert Review of Neurotherapeutics·Hai-Ying M Cheng, Josef M Penninger

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