PMID: 10524574Oct 19, 1999Paper

Basal calcitonin levels and the response to pentagastrin stimulation in patients after kidney transplantation or on chronic hemodialysis as indicators of medullary carcinoma

Thyroid : Official Journal of the American Thyroid Association
H KotzmannH Vierhapper

Abstract

Plasma concentrations of calcitonin (hCT) were determined in 150 patients with chronic renal failure on chronic hemodialysis therapy (CHD) and in 800 patients after successful kidney transplantation (KT). Basal hCT concentrations exceeded 10 pg/mL in 44 of 150 patients (29%) with CHD and in 48 of 800 (6%) in patients with KT. Among these patients with elevated basal hCT, pentagastrin-stimulated concentrations of hCT exceeded 100 pg/mL in 4 patients with CHD and in 7 with KT. Thyroidectomy was performed in 8 patients (5 with KT, 3 with CHD) revealing the presence of medullary thyroid carcinoma (MTC) (n = 2) or of C-cell hyperplasia (n = 6). Two patients with C-cell hyperplasia had the neoplastic form of this disorder. One patient with MTC and 1 with C-cell hyperplasia also presented a papillary microcarcinoma. Stimulated concentrations of hCT were only moderately elevated in the remaining 3 patients and follow-up rather than surgery was deemed appropriate due to their concomitant severe medical problems. In conclusion, basal concentrations of hCT higher than 10 pg/mL are more common in patients with CHD (29%) and after successful KT (6%) than previously described in patients with thyroid nodular disease (3%). In spite of various...Continue Reading

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Citations

Sep 22, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M d'HerbomezJ L Wemeau
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·C ScheubaH Vierhapper
Dec 17, 2005·Thyroid : Official Journal of the American Thyroid Association·H VierhapperS Baumgartner-Parzer
Mar 27, 2007·Thyroid : Official Journal of the American Thyroid Association·M C VantyghemM D'Herbomez
Jun 8, 2000·The American Journal of Surgical Pathology·J E KruegerJ Albores-Saavedra
Mar 3, 2007·Virchows Archiv : an International Journal of Pathology·Claire BléchetSerge Guyétant
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Hossein Gharib, Enrico Papini
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kyra A BorchhardtGere Sunder-Plassmann
May 26, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/AME/ETA Task Force on Thyroid Nodules
Apr 7, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/AME Task Force on Thyroid Nodules
Feb 23, 2018·Journal of Veterinary Internal Medicine·D H N van den BroekR E Jepson
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Georgios KaranikasChristian Pirich
Feb 18, 2003·Endocrine Reviews·Laszlo HegedüsFinn N Bennedbaek
Jan 22, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M BrauckhoffH Dralle

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