Abstract
A 69 yr old man had a 4 mm basal cell carcinoma completely excised from the chin. Numerous hyaline cytoplasmic inclusions were contained within the tumor cells. The inclusions stained intensely red with Masson's trichrome, and immunocytochemically there was prominent rim labelling for keratins (bovine, callus and AE1/3) and muscle-specific actin, the latter more faintly decorating the centre of some inclusions. The inclusions were negative for antibodies to cytokeratin Cam5.2, epithelial membrane antigen (EMA), vimentin, S100, neurofilaments, glial fibrillary acidic protein (GFAP) and carcinoembryonic antigen (CEA) and there was no post Congo red apple green birefringence to indicate amyloid. Ultrastructure indicated the inclusions were composed of proteinaceous material surrounded by a defined rim of tonofilaments in cells showing no degenerative features. The findings suggested aberrant tumor cell keratinization. Familiarization with this rare variant of a common cutaneous carcinoma will alleviate diagnostic difficulties that may arise, particularly in superficial tumor curettage.
References
Mar 1, 1978·Histopathology·J D Lomax-Smith, J G Azzopardi
Jan 1, 1978·The Journal of Dermatologic Surgery and Oncology·T R Wade, A B Ackerman
Nov 1, 1990·Histopathology·T M StarinkJ C Van Der Linden
Jun 1, 1991·The American Journal of Dermatopathology·G M WhiteS Y Liao
Jun 1, 1991·Histopathology·R K al-Talib, J M Theaker
Aug 1, 1991·The Journal of Dermatologic Surgery and Oncology·L Lowe, R P Rapini
Jun 1, 1985·Journal of Cutaneous Pathology·K Hashimoto
Jun 1, 1988·Journal of Cutaneous Pathology·R E Cohen, M T Zaim
Jun 1, 1989·Journal of Cutaneous Pathology·K YonedaS Mori
Dec 1, 1988·Journal of Cutaneous Pathology·G F Oliver, R K Winkelmann
Oct 1, 1982·Ultrastructural Pathology·S M Sajjad, B Mackay
Nov 1, 1983·Cancer·H IwasakiR Mori
Nov 15, 1983·Cancer·L M Looi
Mar 1, 1993·Histopathology·S S BanerjeeA R Mainwaring
Citations
Sep 3, 2011·The American Journal of Dermatopathology·Song ZhengJoan M Mones
Jun 7, 2012·The American Journal of Dermatopathology·Yong HuangYong Li
Dec 1, 1995·Epilepsia·A L RabinowiczW T Couldwell
Aug 29, 2001·Neurosurgery·G E VatesM T Lawton
May 23, 2002·Neurosurgery·Peng-Wei HsuTzu-Kang Lin
Mar 1, 1997·Journal of Neurosurgery·D Y EngK Jaeckle
Jul 1, 1997·Journal of Neurosurgery·S A EnamK L Ho
Feb 9, 1999·Journal of Neurosurgery·V JayI Teshima
Nov 13, 2001·Journal of Neurosurgery·E Tyler-KabaraL D Lunsford
Aug 13, 2015·Journal of Cutaneous Pathology·Sui Wing Winney Chu, Asok Biswas
Apr 25, 2021·BMJ Case Reports·Ayako WatanabeKatsuhiko Enomoto
Feb 20, 2021·The American Journal of Dermatopathology·Tien Anh N TranKonstantinos Linos