PMID: 7541521Jan 1, 1995Paper

Basal cell carcinoma with hyaline inclusions

Pathology
C L James

Abstract

A 69 yr old man had a 4 mm basal cell carcinoma completely excised from the chin. Numerous hyaline cytoplasmic inclusions were contained within the tumor cells. The inclusions stained intensely red with Masson's trichrome, and immunocytochemically there was prominent rim labelling for keratins (bovine, callus and AE1/3) and muscle-specific actin, the latter more faintly decorating the centre of some inclusions. The inclusions were negative for antibodies to cytokeratin Cam5.2, epithelial membrane antigen (EMA), vimentin, S100, neurofilaments, glial fibrillary acidic protein (GFAP) and carcinoembryonic antigen (CEA) and there was no post Congo red apple green birefringence to indicate amyloid. Ultrastructure indicated the inclusions were composed of proteinaceous material surrounded by a defined rim of tonofilaments in cells showing no degenerative features. The findings suggested aberrant tumor cell keratinization. Familiarization with this rare variant of a common cutaneous carcinoma will alleviate diagnostic difficulties that may arise, particularly in superficial tumor curettage.

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Citations

Sep 3, 2011·The American Journal of Dermatopathology·Song ZhengJoan M Mones
Jun 7, 2012·The American Journal of Dermatopathology·Yong HuangYong Li
May 23, 2002·Neurosurgery·Peng-Wei HsuTzu-Kang Lin
Mar 1, 1997·Journal of Neurosurgery·D Y EngK Jaeckle
Jul 1, 1997·Journal of Neurosurgery·S A EnamK L Ho
Nov 13, 2001·Journal of Neurosurgery·E Tyler-KabaraL D Lunsford
Aug 13, 2015·Journal of Cutaneous Pathology·Sui Wing Winney Chu, Asok Biswas
Feb 20, 2021·The American Journal of Dermatopathology·Tien Anh N TranKonstantinos Linos

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Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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