Basal cell carcinoma with matrical differentiation

Annales de pathologie
Gabrielle Goldman-LévyValérie Costes

Abstract

Basal cell carcinoma with matrical differentiation is a very rare variant of basal cell carcinoma. To our knowledge, less than 30 cases have been reported. This tumor is composed of basaloid lobules showing a differentiation toward the pilar matrix cells. Recently, it has been demonstrated that beta-catenin would interfer with physiopathogenesis of matrical tumors, in particular pilomatricomas, but also basal cell carcinomas with matrical differentiation. This is a new case, with immunohistochemical and molecular analysis of beta-catenin, in order to explain its histogenesis.

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Citations

Jun 17, 2016·Head and Neck Pathology·Christopher MarounRoger V Moukarbel

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