Basal cell carcinomas: attack of the hedgehog

Nature Reviews. Cancer
Ervin H Epstein

Abstract

Basal cell carcinomas (BCCs) were essentially a molecular 'black box' until some 12 years ago, when identification of a genetic flaw in a rare subset of patients who have a great propensity to develop BCCs pointed to aberrant Hedgehog signalling as the pivotal defect leading to formation of these tumours. This discovery has facilitated a remarkable increase in our understanding of BCC carcinogenesis and has highlighted the carcinogenic role of this developmental pathway when aberrantly activated in adulthood. Importantly, a phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of these tumours.

References

Nov 1, 1991·British Journal of Cancer·D G EvansJ M Birch
Oct 1, 1991·The Journal of Investigative Dermatology·A SlominskiJ Wortsman
Nov 1, 1989·Journal of the American Academy of Dermatology·N S Goldberg, S S Weiss
Jul 1, 1989·Journal of the American Academy of Dermatology·L H GoldbergJ Alcalay
Oct 1, 1985·The Journal of Clinical Investigation·J A MacLaughlin, M F Holick
Jul 1, 1988·Journal of the American Academy of Dermatology·G L PeckF W Yoder
Jun 23, 1988·The New England Journal of Medicine·K H KraemerG L Peck
Mar 1, 1987·Medicine·R J Gorlin
Feb 1, 1986·Journal of the American Academy of Dermatology·A D JohnsonN B Esterly
Jul 17, 1995·International Journal of Cancer. Journal International Du Cancer·H S BlackS Jaax
Sep 1, 1995·Journal of the American Academy of Dermatology·T Y ChuangE R Farmer
Feb 8, 1995·International Journal of Cancer. Journal International Du Cancer·A KrickerP J Heenan
Feb 8, 1995·International Journal of Cancer. Journal International Du Cancer·A KrickerP J Heenan
May 1, 1994·Journal of the American Academy of Dermatology·D L Miller, Martin A Weinstock
Oct 1, 1993·International Journal of Dermatology·T Y ChuangE R Farmer
Oct 14, 1993·The New England Journal of Medicine·S C ThompsonR Marks
Apr 1, 1996·The Journal of Investigative Dermatology·M WintzenBarbara A Gilchrest
Apr 1, 1996·Photochemistry and Photobiology·D Yarosh, J Klein
Mar 31, 1997·American Journal of Medical Genetics·V E KimonisS J Bale
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·Y HoshidaK Aozasa
Jan 9, 1998·Nature·J XieFrederic J de Sauvage
Apr 16, 1998·Journal of the National Cancer Institute·A OuhtitD R English
Jun 11, 1998·Science·Michael K CooperPhilip A Beachy
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·N BodakL Daya-Grosjean
May 21, 1999·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M Gerber, D Corpet
Dec 28, 1999·The New England Journal of Medicine·Ketty PerisS Chimenti
Mar 4, 2000·Nature Genetics·M GrachtchoukAndrzej A Dlugosz
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·M NilssonRune Toftgård
Jun 8, 2000·Journal of the National Cancer Institute·M Berwick, P Vineis
Jul 8, 2000·The Journal of Biological Chemistry·H HahnA Zimmer
Feb 17, 2001·The Journal of Investigative Dermatology·N F BoxR A Sturm
Mar 20, 2001·American Journal of Human Genetics·M BastiaensLeiden Skin Cancer Study Team
Mar 21, 2001·American Journal of Epidemiology·Margaret R KaragasE R Greenberg
May 12, 2001·The Journal of Investigative Dermatology·J M BonifasErvin H Epstein
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·J XieF McCormick
Sep 21, 2001·The Journal of Investigative Dermatology·K J AshtonL R Griffiths
Jan 26, 2002·Cancer Causes & Control : CCC·H R GuoR R Monson
Feb 7, 2002·Journal of the National Cancer Institute·Margaret R KaragasMartin A Weinstock
May 23, 2002·International Journal of Hygiene and Environmental Health·Margaret R KaragasTor D Tosteson
Aug 8, 2002·The Journal of Investigative Dermatology·Jane M McGregorTimothy Crook
Sep 5, 2002·Photodermatology, Photoimmunology & Photomedicine·T Schwarz
Nov 5, 2002·Genes & Development·James K ChenPhilip A Beachy
Feb 19, 2003·Nature Genetics·Michael NicolasFreddy Radtke
Mar 15, 2003·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Yen-Ching ChenDavid C Christiani
Mar 15, 2003·Journal of the American Academy of Dermatology·Tamara Salam HousmanG John Chen
May 30, 2003·The EMBO Journal·Vladimir GrachtchoukAndrzej A Dlugosz
Oct 14, 2003·The Journal of Biological Chemistry·Rebecca L H BigelowT J McDonnell
Nov 7, 2003·Nature·Danwei HuangfuKathryn V Anderson
Nov 25, 2003·The Journal of Investigative Dermatology·Madeleine DuvicParul Hazarika
May 6, 2004·Cancer Research·Jiali HanDavid J Hunter
May 14, 2004·The Journal of Investigative Dermatology·Thomas EichbergerA M Frischauf
Jun 19, 2004·Science·Lawrence Lum, Philip A Beachy
Sep 14, 2004·Nature·Sunil S KarhadkarPhilip A Beachy
Sep 17, 2004·American Journal of Human Genetics·Jonathan L Rees
Sep 24, 2004·British Journal of Cancer·Jiali HanDavid J Hunter
Dec 18, 2004·Development·Verónica PalmaAriel Ruiz i Altaba
Jan 19, 2005·The Journal of Investigative Dermatology·Annika VogtErvin H Epstein
Jan 20, 2005·The British Journal of Dermatology·Julia ReifenbergerG Reifenberger
May 13, 2005·The British Journal of Dermatology·A AsplundF Pontén
May 21, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert J LipinskiWade Bushman
Jun 17, 2005·Cancer Research·Diane R Wonsey, Maximillian T Follettie
Jun 28, 2005·Journal of Dermatological Science·Brandon G HowellDaniel N Sauder
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Danwei Huangfu, Kathryn V Anderson
Aug 11, 2005·JAMA : the Journal of the American Medical Association·Leslie J ChristensonRandall Roenigk
Sep 2, 2005·Nature·Kevin C CorbitJeremy Reiter
Sep 28, 2005·The Journal of Investigative Dermatology·Rudolph D PaladiniLee L Rubin
Nov 23, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Roger D KleinAllen E Bale
Nov 25, 2005·The New England Journal of Medicine·Adam I RubinDésirée Ratner
Jan 19, 2006·Human Mutation·Erika LindströmPeter G Zaphiropoulos
Jan 20, 2006·Genes & Development·Erik G HuntzickerAnthony E Oro
Feb 21, 2006·Cancer Research·Christelle AdolpheBrandon J Wainwright
Feb 28, 2006·Carcinogenesis·Ranjit Kumar ThirumaranRajiv Kumar
Mar 4, 2006·Carcinogenesis·Katie L MillerHeather H Nelson
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Natalia A RiobóCharles P Emerson
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jiali HanDavid J Hunter
Apr 29, 2006·The Journal of Investigative Dermatology·Muriel LiboutetNadem Soufir
May 3, 2006·The Journal of Biological Chemistry·Neehar BhatiaVladimir S Spiegelman
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Jiali HanDavid J Hunter
Jun 2, 2006·Molecular Carcinogenesis·Jiali HanDavid J Hunter
Jun 17, 2006·Cancer Investigation·Benedito A CarneiroBruce E Brockstein
Jun 23, 2006·European Journal of Human Genetics : EJHG·Shizhong HanYao Li
Aug 10, 2006·PLoS Biology·Maarten F BijlsmaMaikel P Peppelenbosch
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julie B SneddonPatrick O Brown
Oct 5, 2006·Cancer Research·Senthil K RadhakrishnanAndrei L Gartel
Nov 15, 2006·Molecular and Cellular Biology·Yongjun TanRobert H Costa
Nov 30, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jolieke C van der PolsAdèle C Green
Dec 19, 2006·The Journal of Clinical Investigation·Galina A GusarovaRobert H Costa
Dec 19, 2006·Molecular Cancer·Lorraine O'DriscollMartin Clynes
Dec 22, 2006·Journal of Cell Science·Markku Varjosalo, Jussi Taipale
Jan 25, 2007·Journal of Cutaneous Pathology·Christina M ReinischJohannes Pammer
Feb 7, 2007·Human Mutation·Meg R GerstenblithMaria Teresa Landi
Feb 9, 2007·Archives of Histology and Cytology·Hirohito MiuraShuitsu Harada
May 25, 2007·The Journal of Investigative Dermatology·Simin AradBarbara A Gilchrest
Jun 8, 2007·The British Journal of Dermatology·S WilkeningRajiv Kumar
Jul 17, 2007·The Journal of Investigative Dermatology·Hywel C Williams
Jul 21, 2007·Science·Rajat RohatgiMatthew P Scott
Sep 1, 2007·Nature Cell Biology·Rajat Rohatgi, Matthew P Scott
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesca Balordi, Gord Fishell
Jan 9, 2008·Photochemistry and Photobiology·Mark S EllerBarbara A Gilchrest
Jan 18, 2008·The Journal of Investigative Dermatology·Mei YuKevin J McElwee
May 20, 2008·Nature Genetics·Daniel F GudbjartssonKari Stefansson
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dan SegerbäckKari Hemminki

Citations

Oct 20, 2010·Archives of Dermatology·Jean Y TangErvin H Epstein
Apr 22, 2009·International Journal of Colorectal Disease·Hui-Min Chen, Jing-Yuan Fang
Dec 17, 2009·Journal of the American Chemical Society·Shuanhu GaoChuo Chen
Mar 25, 2009·Journal of Medicinal Chemistry·Neeraj MahindrooNaoaki Fujii
May 21, 2013·Cell Death and Differentiation·N S ChariT J McDonnell
Feb 16, 2010·Nature Cell Biology·Khalil Kass YoussefCédric Blanpain
Dec 1, 2012·Nature Cell Biology·David W M Tan, Nick Barker
Jan 22, 2013·Nature Cell Biology·Cédric Blanpain
Jan 20, 2009·Nature Chemical Biology·Benjamin Z StantonStuart L Schreiber
Jul 7, 2009·Nature Genetics·Simon N StaceyKari Stefansson
Sep 29, 2011·Nature Genetics·Simon N StaceyKari Stefansson
Nov 10, 2013·Nature Medicine·Dereck AmakyeMarion Dorsch
May 27, 2011·Nature Reviews. Cancer·Jessica M Y Ng, Tom Curran
Jul 25, 2013·Nature Reviews. Clinical Oncology·Ervin H Epstein
Jun 2, 2012·Nature Reviews. Drug Discovery·Andrzej A DlugoszPeter Kirkpatrick
May 15, 2013·Prostate Cancer and Prostatic Diseases·P De LucaA De Siervi
Dec 29, 2010·Médecine sciences : M/S·Khalil Kass YoussefCédric Blanpain
Sep 4, 2009·The New England Journal of Medicine·Andrzej A Dlugosz, Moshe Talpaz
Sep 4, 2009·The New England Journal of Medicine·Daniel D Von HoffJennifer A Low
Jun 8, 2012·The New England Journal of Medicine·Jean Y TangErvin H Epstein
Jan 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chantal S ColmontG K Patel
Sep 23, 2010·The Journal of Biological Chemistry·Qipeng FanJingwu Xie
Sep 21, 2012·The Journal of Biological Chemistry·Dongsheng GuJingwu Xie
Mar 10, 2009·Human Molecular Genetics·Makoto KunisadaDavid Schlessinger
Mar 16, 2013·Current Opinion in Oncology·Aleksandar SekulicPatricia M LoRusso
Jan 28, 2009·Genes & Development·Jessica D KesslerRobert J Wechsler-Reya
Jun 4, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Charlene LamElizabeth M Billingsley
Jun 17, 2010·Photochemistry and Photobiology·Clio DessiniotiAlexander J Stratigos
Jun 16, 2010·Pigment Cell & Melanoma Research·Meg R GerstenblithMaria Teresa Landi
Jan 11, 2012·Clinical Microbiology Reviews·Georgios GaitanisA Velegraki
Feb 22, 2012·Biochemistry. Biokhimii︠a︡·V L Katanaev, M V Kryuchkov
Dec 15, 2010·Journal of Skin Cancer·Lídia M FreyEva-B Bröcker
Jan 7, 2011·Journal of Skin Cancer·Masahiro NakayamaAkira Hara
May 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tracy TangFrederic J de Sauvage
Jun 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ross McMillan, William Matsui
Jun 9, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles M Rudin
Apr 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antonio JimenoCharles M Rudin
Mar 26, 2011·Cancer Prevention Research·Jean Y TangErvin H Epstein
Apr 27, 2011·The Journal of Clinical Investigation·Marina GrachtchoukAndrzej A Dlugosz
Feb 2, 2012·The Journal of Clinical Investigation·Peggy Myung, Mayumi Ito
Apr 27, 2011·The Journal of Clinical Investigation·Ervin H Epstein
Feb 2, 2012·The Journal of Clinical Investigation·Maria KasperRune Toftgård
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Sachin GuptaPatricia M LoRusso
Jan 22, 2009·Cell Division·Nicola Cranna, Leonie Quinn
Jan 4, 2013·PloS One·Tjinta BrinkhuizenMaurice A M van Steensel
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Doris MangelbergerFritz Aberger
Sep 3, 2013·Journal of Visualized Experiments : JoVE·Dongsheng GuJingwu Xie
Jan 5, 2011·Chinese Journal of Cancer·Hailan LiuJingwu Xie
Jul 2, 2014·Deutsches Ärzteblatt International·Carola BerkingRalf Gutzmer
Mar 4, 2014·Current Dermatology Reports·Shalini V Mohan, Anne Lynn S Chang
Feb 27, 2014·Hand : Official Journal of the American Association for Hand Surgery·Gefei Alex ZhuAnne Lynn S Chang
Feb 1, 2014·Cell Death & Disease·E PantaziM P Philpott
Jan 10, 2014·Human Molecular Genetics·Simon N StaceyKari Stefansson
Jun 6, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·L Hübinger, J Frank
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Stefan Kraft, Scott R Granter
Jul 13, 2014·American Journal of Clinical Dermatology·Lauren BrinJerry D Brewer
Aug 8, 2014·Nature Medicine·Ya-Chieh HsuElaine Fuchs
Oct 5, 2010·Annual Review of Pharmacology and Toxicology·Michael E Dodge, Lawrence Lum
Nov 23, 2010·AJNR. American Journal of Neuroradiology·M D DobbsS P Donahue
Feb 20, 2016·Journal of the American Academy of Dermatology·Prajakta D JajuKavita Y Sarin
Jul 6, 2014·Leukemia & Lymphoma·Lingyun Geng, Xin Wang
Jan 9, 2013·Expert Opinion on Therapeutic Patents·M Kyle Hadden
Oct 17, 2012·The Journal of Cell Biology·Scott X AtwoodAnthony E Oro
May 10, 2013·Expert Opinion on Pharmacotherapy·Jil DreierReinhard Dummer
May 20, 2015·Cancers·Ram Mohan Ram Kumar, Bruno Fuchs
Jul 29, 2010·Expert Opinion on Investigational Drugs·Po-Lin SoErvin H Epstein
May 27, 2009·Expert Opinion on Emerging Drugs·Devalingam MahalingamFrancis J Giles
Apr 30, 2014·Expert Opinion on Emerging Drugs·Jil DreierRainer Kunstfeld
Feb 19, 2015·Current Medical Research and Opinion·Gökmen Umut ErdemNurullah Zengin
May 23, 2012·FEBS Letters·Delphine JavelaudAlain Mauviel
May 23, 2015·International Journal of Oncology·Ashley L SpannAndra R Frost
Sep 27, 2015·The British Journal of Dermatology·A M John, R A Schwartz
Oct 16, 2012·Journal of the American Academy of Dermatology·Jean Y TangMaryam M Asgari
Sep 19, 2012·Progress in Histochemistry and Cytochemistry·Fabio MarongiuEzio Laconi
Aug 22, 2012·Pharmacology & Therapeutics·Fergal C KelleherDavid M Thomas
May 30, 2012·Seminars in Cutaneous Medicine and Surgery·Kim ChongUCSF High Risk Skin Cancer Program
Apr 24, 2012·Hematology/oncology Clinics of North America·Deirdre J Cohen
Apr 10, 2012·Seminars in Oncology·Ragini R KudchadkarRene Gonzalez
Sep 9, 2015·The Journal of Investigative Dermatology·Prajakta D JajuKavita Y Sarin
May 5, 2011·Seminars in Cutaneous Medicine and Surgery·William L CampCraig A Elmets
Mar 15, 2011·Cellular Signalling·Chengxin LiJingwu Xie
Jan 11, 2011·Cancer Treatment Reviews·Apar Kishor Ganti, Anne Kessinger
Aug 11, 2010·Trends in Molecular Medicine·Monique T BarakatMatthew P Scott
Mar 23, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·John R BasileYi-Ling Lin
May 16, 2009·Trends in Pharmacological Sciences·Suzie J Scales, Frederic J de Sauvage
Mar 25, 2011·The Journal of Investigative Dermatology·Hans SkvaraMenno A De Rie
Apr 24, 2009·The Journal of Investigative Dermatology·Masaru Katoh
Jan 29, 2014·The Journal of Investigative Dermatology·Felicite K NoubissiVladimir S Spiegelman
Dec 22, 2009·Molecular BioSystems·Benjamin Z Stanton, Lee F Peng
Nov 26, 2014·Journal of Experimental & Clinical Cancer Research : CR·Shulin ZhangLiang You
Apr 29, 2009·The Australasian Journal of Dermatology·Katarzyna A Mackenzie, Paul D L Maurice
Jun 16, 2014·Journal of the American Academy of Dermatology·Mina Sarah AllyJean Yuh Tang
Mar 15, 2016·Head and Neck Pathology·Scott C BreslerScott R Granter
Sep 2, 2011·Molecular Carcinogenesis·Karin Heby-HenricsonStephan Teglund
Oct 12, 2010·The Laryngoscope·Shivan H AminC Patrick Hybarger
Apr 9, 2013·International Journal of Cancer. Journal International Du Cancer·Naokazu IbukiMichael E Cox
Mar 16, 2013·The British Journal of Dermatology·F R Ali, John Lear
May 1, 2012·The British Journal of Dermatology·M SandF G Bechara
Jan 17, 2012·American Journal of Medical Genetics. Part a·Mamiko EndoToshiyuki Miyashita
Oct 18, 2012·Journal of Cutaneous Pathology·Karolina A PeszMaria M Sasiadek
May 18, 2013·International Journal of Dermatology·Lucinda S Liu, Oscar R Colegio
Jul 16, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anna MleczkoM Leverkus
Mar 17, 2010·ChemMedChem·Stefan Peukert, Karen Miller-Moslin
Mar 19, 2016·Molecular Cancer·Ann Hanna, Lalita A Shevde
Mar 12, 2010·Journal of Neurochemistry·Elisabeth TraiffortMartial Ruat
Sep 23, 2014·The British Journal of Dermatology·I M Leigh
Jun 16, 2010·The Australasian Journal of Dermatology·Sally E de Zwaan, Nikolas K Haass
Jan 25, 2014·American Journal of Physical Anthropology·Daniel L Osborne, Raymond Hames
Aug 18, 2009·The British Journal of Dermatology·R Van HarenA A Sinha
May 29, 2015·RNA Biology·Zhen XingLiuqing Yang
Mar 2, 2016·Radiation Research·Changzhao Li, Mohammad Athar
Jun 7, 2015·European Journal of Pharmacology·Yuji ShimizuMasaharu Nakayama
Aug 25, 2015·Clinical and Experimental Dermatology·S BalciL Tamer
Oct 2, 2012·Journal of Skin Cancer·Frauke NitzkiHeidi Hahn
Oct 6, 2015·Future Oncology·Claudine Piérard-FranchimontGérald E Piérard
Nov 6, 2013·Journal of the American Academy of Dermatology·Anne Lynn S ChangGlen J Weiss
Aug 5, 2015·Current Problems in Cancer·Carlos Prieto-Granada, Paul Rodriguez-Waitkus
Apr 22, 2015·British Journal of Haematology·Alesia A KhanDonal P McLornan
Jun 9, 2015·Molecular Carcinogenesis·Cynthia TilleyRajesh Agarwal
Sep 2, 2015·Drugs·Celeste B Burness
Jun 17, 2015·Biochimica Et Biophysica Acta·Laura Di MagnoGianluca Canettieri
Apr 18, 2012·The Biochemical Journal·Seung-Won ChoiDae-Won Kim
Dec 30, 2014·Molecular Aspects of Medicine·Alessandra di MasiClara Nervi
Feb 11, 2014·Current Opinion in Cell Biology·Morgan O'HayreJ Silvio Gutkind
Dec 29, 2012·Current Opinion in Cell Biology·Xiaoou PanPierre A Coulombe
Jun 2, 2015·Expert Opinion on Pharmacotherapy·Efthymia SouraAlexander J Stratigos
Jun 23, 2015·Bioorganic & Medicinal Chemistry·Tomohiro OhashiSatoshi Sasaki
Jun 23, 2015·Cell Stem Cell·Jean-Christophe LarsimontCédric Blanpain
Feb 4, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Susana Puig, A Berrocal
May 12, 2015·Nature Cell Biology·Ramiro Iglesias-BartolomeJ Silvio Gutkind
Feb 20, 2015·Annals of Plastic Surgery·Jessica A ChingMichael A Harrington
Apr 14, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Arielle N B KauvarAmerican Society for Dermatologic Surgery
Aug 23, 2012·Bioorganic & Medicinal Chemistry·Tomohiro OhashiSatoshi Sasaki
May 25, 2010·Bioorganic & Medicinal Chemistry Letters·Brian S LucasWendy Zhong
Jul 3, 2010·Bioorganic & Medicinal Chemistry Letters·Jacob A KaizermanDustin L McMinn
Apr 10, 2015·Nature Communications·Simon N StaceyKari Stefansson
Feb 14, 2015·European Journal of Medicinal Chemistry·Albert M DeberardinisM Kyle Hadden
Jan 11, 2011·Cancer Cell·Grace Y WangErvin H Epstein
Jun 19, 2012·Mechanisms of Development·Jacob D KageyKenneth H Moberg
May 27, 2014·Reproductive Toxicology·Nicola Powles-Glover
Nov 11, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·R M LucasJ C van der Leun
Jan 1, 2015·Bioorganic & Medicinal Chemistry·Upasana BanerjeeM Kyle Hadden
Jul 18, 2014·Lasers in Medical Science·Nevien A SamyAhmed M Sadek
Jun 9, 2016·Organic & Biomolecular Chemistry·Trieu N TrinhAdam McCluskey
Jun 19, 2016·Journal of the American Academy of Dermatology·Gina P KwonJean Y Tang
Feb 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yingying HongTiejun Li
Jul 28, 2016·The Journal of Investigative Dermatology·Victoria Sherwood, I M Leigh
Jul 28, 2016·Nature·Adriana Sánchez-DanésCédric Blanpain
Aug 19, 2016·Expert Opinion on Pharmacotherapy·Egle RamelyteReinhard Dummer
Apr 16, 2014·Journal of Medicinal Chemistry·Albert M DeberardinisM Kyle Hadden
Sep 2, 2016·Orphanet Journal of Rare Diseases·Anne Lynn S ChangAleksandar Sekulic
Sep 2, 2016·Seminars in Cell & Developmental Biology·Hengbo ZhouHeide L Ford
Jan 23, 2016·Annales de dermatologie et de vénéréologie·N Meyer
Oct 19, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·V KakkasseryL M Heindl
Jul 28, 2016·Acta Oncologica·Jakob Felbo PaulsenAlessandro Venzo
Aug 18, 2016·Retinal Cases & Brief Reports·Nathan D FarleyMichael D Ober
Jan 31, 2017·The American Journal of Dermatopathology·Jonathan J LeeMai P Hoang
Feb 22, 2017·The British Journal of Dermatology·J A C VerkouterenT Nijsten
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer A Low, Frederic J de Sauvage
Feb 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J KimJean Y Tang
Feb 2, 2017·The Journal of Investigative Dermatology·Xianghui MaZhengquan Yu
Mar 21, 2017·Organic & Biomolecular Chemistry·Trieu N TrinhAdam McCluskey
Feb 11, 2015·Expert Reviews in Molecular Medicine·Silvia Pandolfi, Barbara Stecca
Sep 24, 2015·Ophthalmic Plastic and Reconstructive Surgery·Vasilios P Papastefanou, Cornelius René
Jan 19, 2010·Veterinary Pathology·H-Y LeeJ-H Park
Sep 2, 2016·Therapeutic Advances in Medical Oncology·Sirunya SilapuntMichael R Migden
May 20, 2017·Current Opinion in Pediatrics·Alexander L FogelJoyce M C Teng
Jan 1, 2011·Cancers·Giulia SpalloneAntonio Costanzo
Nov 23, 2017·International Journal of Molecular Sciences·Cristina PellegriniMaria Concetta Fargnoli
Jan 6, 2018·Biomedicines·Dario DidonaCarmen Cantisani
Jun 20, 2017·The British Journal of Dermatology·Clio DessiniotiAlexander J Stratigos
Apr 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miroslava DidiasovaMalgorzata Wygrecka
Dec 21, 2017·F1000Research·Mariam Totonchy, David J Leffell
Aug 29, 2018·Lasers in Surgery and Medicine·Uffe H OlesenMerete Haedersdal
Sep 17, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M NikanjamRazelle Kurzrock
Feb 12, 2019·Current Treatment Options in Oncology·Keiji Tanese
Nov 8, 2018·Endocrine-related Cancer·Iuri Martin GoemannAna Luiza Maia
Mar 27, 2019·Future Medicinal Chemistry·Christian Espinosa-BustosCristian O Salas
Aug 28, 2014·European Journal of Human Genetics : EJHG·Binnaz YasarD Gareth Evans
Apr 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kateryna V LaikovaAnatoly V Kubyshkin
May 4, 2013·Nature Reviews. Cancer·Morgan O'HayreJ Silvio Gutkind
Mar 3, 2012·G3 : Genes - Genomes - Genetics·Christopher HeffelfingerAllen E Bale
Dec 18, 2012·Annals of Plastic Surgery·Tyler M AngelosBrian A Janz
Jul 25, 2018·The EMBO Journal·Matilde M Miranda, William E Lowry
Jul 25, 2018·The EMBO Journal·Dejan MaglicFernando D Camargo
Jun 8, 2018·EMBO Reports·Maud DebaugniesCédric Blanpain
Apr 28, 2019·Cells·Natalia A Riobo-Del GaldoEva V Wertheimer
May 24, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Richard A GrahamCornelis E C A Hop
Aug 23, 2019·The American Journal of Dermatopathology·B BancalariOnofre Sanmartin
Oct 4, 2019·Clinical and Experimental Dermatology·H J MorganG K Patel
Dec 14, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·I M Leigh
Mar 25, 2020·International Ophthalmology Clinics·Davin C Ashraf, M Reza Vagefi
Mar 3, 2020·Photochemistry and Photobiology·Jihoon W LeeMasaoki Kawasumi
May 15, 2020·The Journal of Dermatological Treatment·Gabriel SchnetzlerRoberto Mingrino
Apr 17, 2020·Experimental Dermatology·Amir Hossein SaeidianNeda Nikbakht
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Giovanni NicolettiAngela Faga
Nov 6, 2018·The Journal of Dermatological Treatment·Vincenzo De GiorgiPiero Covarelli
May 9, 2020·International Journal of Cancer. Journal International Du Cancer·Thais BasiliJorge S Reis-Filho
Apr 23, 2010·Clinical Pharmacology and Therapeutics·Glen J Weiss, Daniel D Von Hoff
Sep 12, 2014·International Journal of Dermatology·Karolina A PeszMaria M Sasiadek
Jun 21, 2017·Dermatologic Therapy·Omid ZargariSiamak Geranmayeh
Mar 20, 2018·Frontiers in Pediatrics·Antonia ReimerCristina Has
Feb 24, 2019·International Journal of Molecular Sciences·Aikaterini F GiannopoulouDimitrios J Stravopodis
Apr 18, 2019·Cancers·Elisabeth PeerFritz Aberger
Aug 24, 2019·Cancers·Christopher M R LangWen-Hui Lien
Aug 20, 2019·Expert Review of Anticancer Therapy·Rory M ShallisAmer M Zeidan
Nov 21, 2019·International Journal of Molecular Sciences·Artem SmirnovEleonora Candi
Apr 17, 2020·Dermatology and Therapy·Alessia VillaniMassimiliano Scalvenzi
Sep 29, 2015·Oncotarget·Sandeep C ChaudharyMohammad Athar
Jul 11, 2018·International Journal of Environmental Research and Public Health·Felicite K NoubissiPaul B Tchounwou
Oct 10, 2018·Nature·Adriana Sánchez-DanésCédric Blanpain
Oct 24, 2019·Anais Brasileiros De Dermatologia·Denis MiyashiroCyro Festa Neto
Jan 29, 2020·Scientific Reports·Amir SternfeldNitza Goldenberg-Cohen
Apr 18, 2017·Expert Opinion on Pharmacotherapy·Teresa Amaral, Claus Garbe
Jul 22, 2018·Drugs·James E Frampton, Nicole Basset-Séguin
Dec 1, 2018·Journal of Skin Cancer·Firas Al-QarqazMohammad Alqudah
Jul 30, 2019·Frontiers in Medicine·Keiji TaneseTakeru Funakoshi
Jul 31, 2019·Current Oncology Reports·Ashley AlbertRoss I S Zbar
May 16, 2020·Scientific Reports·Maria Giovanna MaturoRajiv Kumar
Nov 30, 2019·Frontiers in Genetics·Noriaki SasaiToru Kondo
Mar 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chan FengChunyan Dong
Apr 8, 2020·Cells·Manel B HammoudaJennifer Y Zhang
Sep 23, 2020·Cells·Daniel DohenyHui-Wen Lo
Oct 19, 2010·Journal of Neuro-oncology·Joze PizemAndrej Cör
May 22, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Filomena RussoPaolo Taddeucci
Jun 24, 2018·Virchows Archiv : an International Journal of Pathology·Vera BaurErwin S Schultz
Feb 21, 2019·Nature Reviews. Clinical Oncology·Subotheni ThavaneswaranDavid M Thomas
Dec 24, 2019·Frontiers in Genetics·Joanna PyczekHeidi Hahn
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Tobey J Macdonald
Sep 13, 2017·Cancers·Severine Cao, Vinod E Nambudiri
Apr 5, 2018·Journal of Developmental Biology·Yoshinori Abe, Nobuyuki Tanaka
Jan 24, 2020·In Vitro Cellular & Developmental Biology. Animal·Tatiana MendezAddy Alt-Holland
Aug 23, 2019·Acta chirurgica Belgica·Jos VellemanJan J Vranckx
Sep 26, 2020·Journal of Internal Medicine·B M Lichtenberger, M Kasper
Jan 7, 2010·Cancer Prevention Research·Charles M Rudin
Sep 23, 2010·Cancer Prevention Research·Craig D Peacock, Charles M Rudin
Jan 28, 2010·Cancer Prevention Research·John L Clifford, John DiGiovanni
Dec 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan GoldmanDaniel W Bowles
May 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ivor Caro, Jennifer A Low
Jul 21, 2011·Cancer Research·Ciara Metcalfe, Frederic J de Sauvage
Feb 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia M LoRussoDaniel D Von Hoff
Aug 29, 2014·Cancer Research·Colin J PalmerBoris Reizis
Feb 22, 2018·Cancer Research·Muhammad M RahmanGraham W Neill
Oct 3, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·José BaselgaEva Szabo
Mar 22, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael AxelsonRichard Pazdur
Aug 31, 2014·Cancer Research·Mohammad AtharDavid R Bickers
Oct 25, 2013·Cancer Research·Ciara MetcalfeFrederic J de Sauvage
Dec 22, 2020·Molecular and Cellular Endocrinology·Shabnam MassahRalph Buttyan
Dec 9, 2020·Anais Brasileiros De Dermatologia·Maria Carolina FidelisRenata Ferreira Magalhães
Jan 27, 2021·International Journal of Molecular Sciences·Sidney IrianaNeelam Sharma-Walia
Oct 16, 2020·Expert Opinion on Drug Safety·Alessia VillaniMassimiliano Scalvenzi
Oct 30, 2020·Biomedicines·Luca FaniaElena Dellambra
Jan 1, 2019·Anais Brasileiros De Dermatologia·Denis MiyashiroCyro Festa Neto
Nov 19, 2020·International Journal of Molecular Sciences·Anna PassarelliRaffaele Conca
Feb 18, 2021·Expert Review of Anticancer Therapy·Shawn M Sarkaria, Mark L Heaney
Feb 27, 2021·Pediatric Hematology and Oncology·Michael AbeleMartin Ebinger

Related Concepts

Antineoplastic Agents
Basal Cell Nevus Syndrome
Pigmented Basal Cell Carcinoma
Hormone Receptors, Cell Surface
Malignant Neoplasm of Skin
Signal Transduction
Genetic Predisposition to Disease
Hedgehog Proteins
Basal Cell Carcinoma
Clinical Trials

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.