Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ann D CohenWilliam E Klunk

Abstract

Inverse correlations between amyloid-beta (Abeta) load measured by Pittsburgh Compound-B (PiB) positron emission tomography (PET) and cerebral metabolism using [(18)F]fluoro-2-deoxy-d-glucose (FDG) in Alzheimer's disease (AD) patients, suggest local Abeta-induced metabolic insults. However, this relationship has not been well studied in mild cognitive impairment (MCI) or amyloid-positive controls. Here, we explored associations of Abeta deposition with metabolism via both region-of-interest-based and voxel-based analyses in amyloid-positive control subjects and patients with MCI or AD. Metabolism in parietal and precuneus cortices of AD patients was negatively correlated with PiB retention locally, and more distantly with PiB retention in frontal cortex. In amyloid-positive controls, no clear patterns in correlations were observed. In MCI patients, there were essentially no significant, negative correlations, but there were frequent significant positive correlations between metabolism and PiB retention. Metabolism in anterior cingulate showed positive correlations with PiB in most brain areas in MCI, and metabolism and PiB retention were positively correlated locally in precuneus/parietal cortex. However, there was no significa...Continue Reading

References

Mar 1, 1987·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·J T BeckerK L McGonigle-Gibson
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Dec 28, 1999·Alzheimer Disease and Associated Disorders·D S WolfS S Mirra
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·G W SmallM E Phelps
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
May 6, 2003·Journal of Cognitive Neuroscience·Kristen A McKiernanJeffrey R Binder
Jun 20, 2003·Journal of Clinical and Experimental Neuropsychology·Yaakov SternBrian Rakitin
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Mar 18, 2004·Neuroimaging Clinics of North America·Satoshi Minoshima
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Feb 8, 2005·Radiologic Clinics of North America·Daniel H S Silverman, Abass Alavi
Jun 10, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie C PriceChester A Mathis
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark A Mintun
Dec 21, 2005·Neuron·John R CirritoDavid M Holtzman
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
May 10, 2006·Archives of Neurology·Ronald C PetersenEmre Kokmen
Jun 15, 2006·Alzheimer Disease and Associated Disorders·Yaakov Stern
Jul 15, 2006·Experimental Gerontology·Lisa MosconiMony J de Leon
Jul 21, 2006·Brain : a Journal of Neurology·Henry EnglerAgneta Nordberg
May 15, 2007·Neurobiology of Aging·Anton ForsbergAgneta Nordberg
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William E KlunkSteven T DeKosky
Aug 21, 2007·Brain : a Journal of Neurology·Norman L FosterSatoshi Minoshima
Sep 12, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·S L MillerB C Dickerson
Feb 27, 2008·Annals of Neurology·Ahmadul KadirAgneta Nordberg
Mar 15, 2008·Brain : a Journal of Neurology·Milos D IkonomovicSteven T DeKosky
May 1, 2008·The British Journal of Radiology·K HerholzM Jones
Jun 21, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Yi LiMony J de Leon
Jul 22, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Norman L FosterRobert A Koeppe

❮ Previous
Next ❯

Citations

May 4, 2010·Molecular Neurobiology·Sally A Frautschy, Greg M Cole
Jun 12, 2013·Nature Reviews. Neurology·Jessica B LangbaumEric M Reiman
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrei G VlassenkoMark A Mintun
Apr 12, 2011·Brain : a Journal of Neurology·Prashanthi VemuriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 15, 2011·Brain : a Journal of Neurology·Alexander DrzezgaReisa A Sperling
Nov 1, 2011·Cerebral Cortex·Michael EwersUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Keith A JohnsonWilliam E Klunk
Mar 25, 2010·Science Signaling·Mark P Mattson
Sep 13, 2014·Future Neurology·Ai-Ling Lin, Douglas L Rothman
May 9, 2014·Neurobiology of Aging·Vanja KljajevicUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 10, 2013·Annual Review of Clinical Psychology·Shannon L Risacher, Andrew J Saykin
Mar 13, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Sofie M AdriaanseBart N M van Berckel
Aug 1, 2014·European Journal of Nuclear Medicine and Molecular Imaging·I L Han ChooAgneta Nordberg
Jan 13, 2015·Diabetes·Auriel A WilletteUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 12, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Stefan TeipelUNKNOWN Alzheimer´s Disease Neuroimaging Initiative
Sep 11, 2012·Statistics in Medicine·Gina M D'Angelo, Lisa A Weissfeld
Oct 1, 2015·Brain : a Journal of Neurology·Andre AltmannUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 27, 2015·Neurology·Eider M Arenaza-UrquijoGaël Chételat
Sep 1, 2015·Neuropsychology Review·Shailendra SegobinFrancis Eustache
Aug 19, 2015·Brain : a Journal of Neurology·Lars FringsPhilipp T Meyer
Sep 1, 2015·Frontiers in Aging Neuroscience·Eider M Arenaza-UrquijoGaël Chételat
May 13, 2014·NeuroImage. Clinical·Robert LaforceGil D Rabinovici
Aug 6, 2013·Neuropsychologia·Robert D NebesWilliam E Klunk
Mar 25, 2015·Brain : a Journal of Neurology·Howard J Aizenstein, William E Klunk
Mar 15, 2014·Brain : a Journal of Neurology·Niklas MattssonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 1, 2014·Brain : a Journal of Neurology·Hyun Kook LimHoward J Aizenstein
Oct 1, 2014·European Journal of Nuclear Medicine and Molecular Imaging·A AshrafP Edison
May 6, 2014·Molecular Neurobiology·Wei XuLan Tan
Jul 6, 2016·Frontiers in Neuroinformatics·Sulantha MathotaarachchiPedro Rosa-Neto
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marc Aurel Busche, Arthur Konnerth
Nov 20, 2012·Neurobiology of Aging·Andrew B WolfJon Valla
Oct 16, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Scott E CountsElliott J Mufson
Nov 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tammie L S BenzingerJohn C Morris
Mar 3, 2017·Annals of Neurology·Bernard J HanseeuwKeith A Johnson
Jan 21, 2017·Neuroscience and Biobehavioral Reviews·John Dominic MedagliaDanielle S Bassett
Dec 3, 2016·Journal of Alzheimer's Disease : JAD·Sneha PandyaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 22, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julie C Price
Oct 18, 2015·Neurobiology of Aging·Miguel Ángel Araque CaballeroUNKNOWN Alzheimer's Disease Neuroimaging Initative (ADNI)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Julie C PriceChester A Mathis
Annals of Neurology
David A WolkSteven T De-Kosky
© 2022 Meta ULC. All rights reserved