Abstract
Terminal duct lobular unit (TDLU) is widely accepted as the origin of ductal carcinoma in situ of breast. The differentiation states of myoepithelial cells of breast ductal system hint the development of breast hyperplastic lesions. Basal cytokeratin (CK) phenotypes indicate the differentiation of myoepithelial cells. Using antibodies of CK5/6, CK14, and CK17, this study reports the basal CK phenotypes of myoepithelial cells in 20 foci of normal breast, 20 usual ductal hyperplasias, 36 ductal carcinomas in situ (DCIS), and 28 sclerosing adenosis (SA). The results showed that the positive staining of basal CKs of myoepithelial cells in normal ducts were significantly higher than those in normal lobules. The basal CK expression of myoepithelial cells of DCIS and usual ductal hyperplasia was similar to that of normal duct, whereas that of SA was similar to that of normal lobule. We propose a modified model of TDLU origin of intraductal carcinoma that most of DCIS originate from terminal ducts of TDLU, whereas most SA originate from lobules.
References
Nov 1, 1991·American Journal of Clinical Pathology·H Battifora
Jan 1, 1983·Differentiation; Research in Biological Diversity·R MollW W Franke
Jan 1, 1980·Pathology, Research and Practice·S R Wellings
Jan 27, 1999·Developmental Biology·C PéchouxO W Petersen
Aug 30, 2000·Nature·C M PerouD Botstein
Apr 25, 2003·Experimental and Molecular Pathology·Sanford H Barsky
Jul 16, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Agnes BánkfalviWerner Boecker
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Jan 11, 2005·The Journal of Pathology·Peter T SimpsonSunil R Lakhani
Jul 1, 2005·Breast Cancer Research : BCR·Barry A GustersonTorsten Stein
Sep 20, 2005·Breast Cancer Research : BCR·Melissa C AdrianceMina J Bissell
Jun 30, 2006·Journal of Mammary Gland Biology and Neoplasia·Kornelia Polyak, Min Hu
Oct 22, 2008·The American Journal of Surgical Pathology·Justin B HilsonLaura C Collins
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Ole William Petersen, Kornelia Polyak
May 14, 2010·The American Journal of Surgical Pathology·Justin B HilsonLaura C Collins