Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Li ChenZhi-Li Huang

Abstract

The basal forebrain (BF) cholinergic neurons have long been thought to be involved in behavioral wakefulness and cortical activation. However, owing to the heterogeneity of BF neurons and poor selectivity of traditional methods, the precise role of BF cholinergic neurons in regulating the sleep-wake cycle remains unclear. We investigated the effects of cell-selective manipulation of BF cholinergic neurons on the sleep-wake behavior and electroencephalogram (EEG) power spectrum using the pharmacogenetic technique, the 'designer receptors exclusively activated by designer drugs (DREADD)' approach, and ChAT-IRES-Cre mice. Our results showed that activation of BF cholinergic neurons expressing hM3Dq receptors significantly and lastingly decreased the EEG delta power spectrum, produced low-delta non-rapid eye movement sleep, and slightly increased wakefulness in both light and dark phases, whereas inhibition of BF cholinergic neurons expressing hM4Di receptors significantly increased EEG delta power spectrum and slightly decreased wakefulness. Next, the projections of BF cholinergic neurons were traced by humanized Renilla green fluorescent protein (hrGFP). Abundant and highly dense hrGFP-positive fibers were observed in the seconda...Continue Reading

References

Aug 1, 1987·The Journal of Comparative Neurology·A E HallangerB H Wainer
Jan 1, 1987·Journal of Neurophysiology·M SteriadeM Deschênes
Jul 16, 1993·Science·M von KrosigkD A McCormick
May 9, 2000·Nature·T GallopinM Serafin
Sep 23, 2000·Behavioural Brain Research·L Zaborszky, A Duque
Jun 18, 2002·The Journal of Physiology·A JacksonR N Lemon
Aug 3, 2002·Nature Reviews. Neuroscience·Edward F Pace-Schott, J Allan Hobson
Jun 21, 2005·Nature Neuroscience·Zhi-Li HuangOsamu Hayaishi
Sep 27, 2005·Trends in Pharmacological Sciences·Barbara E Jones
Oct 28, 2006·The European Journal of Neuroscience·Carlos A Blanco-CenturionPriyattam J Shiromani
Dec 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos Blanco-CenturionPriyattam J Shiromani
Aug 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei-Min QuYoshihiro Urade
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oum Kaltoum HassaniBarbara E Jones
Mar 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei-Min QuZhi-Li Huang
Feb 1, 2011·The Journal of Comparative Neurology·Patrick M FullerJun Lu
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael LazarusJiang-Fan Chen
Oct 16, 2012·Brain Research·Martilias S Farrell, Bryan L Roth
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Gang SunMichael Beierlein
Feb 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun YangRitchie E Brown
Aug 19, 2014·Nature Neuroscience·Christelle AnacletPatrick M Fuller
Oct 18, 2014·Sleep·Simal Ozen Irmak, Luis de Lecea
Oct 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan Diego Pita-AlmenarMichael Beierlein

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Citations

Dec 6, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ada Eban-RothschildLuis de Lecea
Oct 14, 2017·Sleep·Christine M WalshThomas C Neylan
Jan 20, 2018·Physiological Reviews·Deniz Atasoy, Scott M Sternson
Oct 6, 2017·Scientific Reports·Teng FangZhi-Li Huang
Mar 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Feng ZhangWeidong Le
Dec 19, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Harumi HottaMark Stewart
Sep 22, 2020·Journal of Alzheimer's Disease : JAD·Claudio Del PercioUNKNOWN PharmaCog Consortium
Apr 8, 2017·Sleep and Biological Rhythms·Huan-Xin SunSu-Rong Yang
May 5, 2017·Light, Science & Applications·Ze ZhangZhi-Li Huang
May 10, 2019·Frontiers in Neuroscience·Ze-Ka ChenZhi-Li Huang
Feb 6, 2020·Frontiers in Neuroscience·Rikuhiro G Yamada, Hiroki R Ueda
Jan 23, 2018·Frontiers in Neural Circuits·Daniel W SparksEvelyn K Lambe
Feb 26, 2020·Neuroscience Bulletin·Han GuoZhi-Li Huang
Nov 12, 2020·The International Journal of Neuroscience·Chengxi LiuTian Yu
Dec 3, 2020·International Journal of Molecular Sciences·Susanna LopezClaudio Babiloni
May 16, 2018·Sleep Medicine Clinics·Sebastian C Holst, Hans-Peter Landolt
Mar 16, 2021·Frontiers in Neuroscience·Qingshuo MengJiayi Zhang
Aug 30, 2018·Cell Reports·Yasutaka NiwaHiroki R Ueda
Apr 13, 2021·Frontiers in Neuroscience·Qi XuZhi-Li Huang
Mar 14, 2021·Journal of Neuroscience Research·Ren-Fei WangLu Wang
Jul 11, 2020·Current Opinion in Physiology·Heinrich S Gompf, Christelle Anaclet
Aug 17, 2021·British Journal of Pharmacology·Yan-Fei YangZhi-Li Huang
Dec 2, 2021·Advanced Healthcare Materials·Yang YangChangyou Zhan

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