Basal Forebrain Nuclei Display Distinct Projecting Pathways and Functional Circuits to Sensory Primary and Prefrontal Cortices in the Rat

Frontiers in Neuroanatomy
Irene Chaves-CoiraMargarita Rodrigo-Angulo

Abstract

Recent evidence supports that specific projections between different basal forebrain (BF) nuclei and their cortical targets are necessary to modulate cognitive functions in the cortex. We tested the hypothesis of the existence of specific neuronal populations in the BF linking with specific sensory, motor, and prefrontal cortices in rats. Neuronal tracing techniques were performed using retrograde tracers injected in the primary somatosensory (S1), auditory (A1), and visual (V1) cortical areas, in the medial prefrontal cortex (mPFC) as well as in BF nuclei. Results indicate that the vertical and horizontal diagonal band of Broca (VDB/HDB) nuclei target specific sensory cortical areas and maintains reciprocal projections with the prelimbic/infralimbic (PL/IL) area of the mPFC. The basal magnocellular nucleus (B nucleus) has more widespread targets in the sensory-motor cortex and does not project to the PL/IL cortex. Optogenetic stimulation was used to establish if BF neurons modulate whisker responses recorded in S1 and PL/IL cortices. We drove the expression of high levels of channelrhodopsin-2, tagged with a fluorescent protein (ChR2-eYFP) by injection of a virus in HDB or B nuclei. Blue-light pulses were delivered to the BF t...Continue Reading

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Citations

May 18, 2020·International Journal of Molecular Sciences·Kai K KummerMichaela Kress
Jul 3, 2020·Scientific Reports·Erik BöhmMarkus Rothermel
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Dec 18, 2020·Frontiers in Neuroscience·Anjum ParkarDinesh Pal
Aug 28, 2020·IScience·Lore M PeetersGeorgios A Keliris
Apr 12, 2020·Neuroscience·D Fernández de SevillaW Buño
Jun 28, 2021·Neurobiology of Learning and Memory·Shogo SomaSatoshi Shimegi
Sep 21, 2021·Frontiers in Aging Neuroscience·Jonathan A Zegarra-ValdiviaAngel Nuñez

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Methods Mentioned

BETA
transfection

Software Mentioned

Tile Scan
Spike
Graph Pad Prism
LAS AF

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