Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors

Frontiers in Neurology
Stefan J TeipelAlzheimer Precision Medicine Initiative (APMI)

Abstract

Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes might represent useful instruments for the prediction of cognitive decline. The primary objective was to determine the predictive value of hippocampus and basal forebrain volumes for global and domain specific cognitive decline in AD dementia during cholinergic treatment. Methods: We used MRI and cognitive data from 124 patients with the clinical diagnosis of AD dementia, derived from the ADNI-1 cohort, who were on standard of care cholinesterase inhibitor treatment during a follow-up period between 0.4 and 3.1 years. We used linear mixed effects models with cognitive function as outcome to assess the main effects as well as two-way interactions between baseline volumes and time controlling for age, sex, and total intracranial volume. This model accounts for individual variation in follow-up times. Results: Basal forebrain volume, but not hippocampus volume, was a significant predictor of rates of global cognitive decline. Larger volumes were associated with smaller rates of cognitive decline. Left hippocampus vo...Continue Reading

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Citations

Feb 28, 2019·Frontiers in Neuroscience·A Claudio CuelloHélène Hall
Feb 26, 2019·Frontiers in Neuroscience·Sumonto MitraMaria Eriksdotter
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Mar 13, 2021·NeuroImage. Clinical·Julia SchumacherAlan J Thomas
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Jul 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mihai AvramChristian Sorg
Aug 31, 2021·Molecular Psychiatry·Harald HampelAndrea Vergallo

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