PMID: 15229069Jul 2, 2004Paper

Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study

The American Journal of Psychiatry
Bangalore N GangadharMatcheri S Keshavan

Abstract

This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia. Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent (31)P MRS. The phosphocreatine/total phosphorus and phosphocreatine/total ATP ratios in both basal ganglia were significantly lower in patients. Schizophrenia patients showed features of increased metabolism in the basal ganglia consistent with impaired activity of the frontostriatal pathways.

Citations

Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Uta SailerAndreas Straube
Mar 12, 2008·Wiener medizinische Wochenschrift·Gerrit N Brandt, Raphael M Bonelli
May 9, 2007·Schizophrenia Bulletin·Andreas Konrad, Georg Winterer
Oct 13, 2012·International Review of Psychiatry·Janardhanan C NarayanaswamyBangalore N Gangadhar
Oct 7, 2006·Acta Psychiatrica Scandinavica·P N JayakumarB N Gangadhar
Mar 30, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bangalore N GangadharMatcheri S Keshavan
Aug 1, 2015·Journal of Psychiatric Research·Cagri YukselDost Ongur
Jul 22, 2014·Asian Journal of Psychiatry·Venkataram ShivakumarBangalore N Gangadhar
Jul 15, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Oded Bergman, Dorit Ben-Shachar
Apr 28, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peiyan Ni, Sangmi Chung
Apr 19, 2007·Neurochemical Research·Gulnur Sh BurbaevaElizabeta Mukaetova-Ladinska
Nov 24, 2020·The European Journal of Neuroscience·Angeliki-Maria VlaikouMichaela D Filiou

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