PMID: 8590789Oct 1, 1995Paper

Basal glucose turnover in Psammomys obesus. An animal model of type 2 (non-insulin-dependent) diabetes mellitus

Acta Diabetologica
R HabitoG R Collier

Abstract

The aim of this study was to examine whole-body glucose turnover and glucose uptake into individual tissues in Psammomys obesus. The animals were classified according to the level of circulating glucose and insulin in the fed state: group A was normoglycaemic and normoinsulinaemic (glucose < 8.0 mmol/l), insulin < 150 mU/l), group B was normoglycaemic and hyperinsulinaemic (glucose < 8.0 mmol/l, insulin > or = 150 mU/l), and group C was hyperglycaemic and hyperinsulinaemic (glucose > or = 8.0 mmol/l, insulin 150 mU/l). The animals were deprived of food for 6 h, after which they were anaesthetized and cannulated, using the jugular vein for infusions and the carotid artery for blood sampling. Whole-body glucose turnover was measured using a primed-continuous infusion of 6-[3H]-glucose and saline to quantitatively assess hepatic glucose production (HGP), glucose disposal (Rd), and the metabolic clearance rate of glucose (MCR). Following the 2-h infusion period, the glucose metabolic index (Rg') of individual tissues was measured using a fixed-dose bolus of 2-deoxy-[14C] glucose. Under the steady-state conditions of the experiment, HGP was assumed to be equal to Rd, and both variables were found to be significantly correlated to th...Continue Reading

References

Oct 1, 1992·Diabetes/metabolism Reviews·E Shafrir
Mar 1, 1992·Diabetes Care·A Consoli
Dec 1, 1987·Metabolism: Clinical and Experimental·D SmithR A DeFronzo
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·H KanetyA Karasik
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Feb 14, 1964·Science·K SCHMIDT-NIELSEND B HACKEL

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Citations

Jun 25, 2002·Annals of the New York Academy of Sciences·Greg CollierGuy Augert
Nov 5, 1997·Annals of the New York Academy of Sciences·G R CollierP Zimmet
May 29, 2002·Diabetes·Ken WalderGreg R Collier
Nov 5, 1997·Annals of the New York Academy of Sciences·P LewandowskiG R Collier
Feb 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rita Kohen AvramogluKhosrow Adeli

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