Basal hyperinsulinemia beyond a threshold predicts major adverse cardiac events at 1 year after coronary angiogram in type 2 diabetes mellitus: a retrospective cohort study

Diabetology & Metabolic Syndrome
Mukund SrinivasanChakrapani Mahabala

Abstract

There is a substantial reduction in cardiovascular related morbidity and mortality in the general population attributed to improved treatment of cardiac risk factors and disease, the same magnitude of benefit has not been observed in those with diabetes mellitus. The aim of the present study was to evaluate factors associated with the cardiac outcome at 1 year after coronary angiogram in patients with type 2 diabetes mellitus and to compare the outcomes with nondiabetics. A retrospective cohort study was carried out in subjects who underwent coronary angiogram for an evaluation of CAD, with follow-up data available for period of 12 months. The data consisted of 208 type 2 diabetic and 75 non-diabetic patients. Clinical, anthropometric and other biochemical risk factors of the study participants were recorded. Univariate and multivariate cox proportional hazard regression analyses were performed to evaluate the relation between the cardiovascular risk factors and major adverse cardiac events (MACE). At 1 year, MACE was observed in 50 (24.04%) type 2 diabetic subjects, which included non-fatal myocardial infarction 24 (11.54%), target vessel revascularization 15 (7.21%) and death 11 (5.29%). The area under the curve for insulin i...Continue Reading

References

Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K R TuttleR Short
Dec 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Masanobu YanaseMasato Watarai
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Richard A KronmalGregory L Burke
Feb 24, 2006·Endocrine Reviews·Julie NigroPeter J Little
Apr 17, 2007·Journal of the American College of Cardiology·UNKNOWN BARI Investigators
Nov 20, 2009·International Journal of Cardiology·Ronald G GarcíaPatricio López-Jaramillo
Nov 6, 2012·The New England Journal of Medicine·Michael E FarkouhUNKNOWN FREEDOM Trial Investigators
Feb 16, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arie Pieter KappeteinUNKNOWN SYNTAX Investigators
Mar 5, 2013·The Journal of Clinical Investigation·Kieren J MatherAlain D Baron
Dec 10, 2013·Lancet·Tiinamaija TuomiLeif Groop
Dec 19, 2013·North American Journal of Medical Sciences·Mukund P SrinivasanChakrapani Mahabala
Sep 23, 2014·Journal of the American College of Cardiology·George D DangasUNKNOWN FREEDOM Investigators

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

CARDia
SYNTAX
BARI
Statistical Package for Social Sciences ( SPSS
FREEDOM

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CV Disorders & Type 2 Diabetes

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