PMID: 15240688Jul 9, 2004Paper

Basal Igalpha/Igbeta signals trigger the coordinated initiation of pre-B cell antigen receptor-dependent processes

The Journal of Immunology : Official Journal of the American Association of Immunologists
E M Fuentes-PananáJohn G Monroe

Abstract

The pro-B to pre-B transition during B cell development is dependent upon surface expression of a signaling competent pre-B cell Ag receptor (pre-BCR). Although the mature form of the BCR requires ligand-induced aggregation to trigger responses, the requirement for ligand-induced pre-BCR aggregation in promoting B cell development remains a matter of significant debate. In this study, we used transmission electron microscopy on murine primary pro-B cells and pre-B cells to analyze the aggregation state of the pre-BCR. Although aggregation can be induced and visualized following cross-linking by Abs to the pre-BCR complex, our analyses indicate that the pre-BCR is expressed on the surface of resting cells primarily in a nonaggregated state. To evaluate the degree to which basal signals mediated through nonaggregated pre-BCR complexes can promote pre-BCR-dependent processes, we used a surrogate pre-BCR consisting of the cytoplasmic regions of Igalpha/Igbeta that is targeted to the inner leaflet of the plasma membrane of primary pro-B cells. We observed enhanced proliferation in the presence of low IL-7, suppression of V(H)(D)J(H) recombination, and induced kappa light (L) chain recombination and cytoplasmic kappa L chain protein ...Continue Reading

References

May 1, 1991·The Journal of Experimental Medicine·R R HardyK Hayakawa
Apr 14, 1983·Nature·S Tonegawa
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y AokiS Pillai
Aug 1, 1995·The Journal of Experimental Medicine·E L Prak, M Weigert
Jun 1, 1993·European Journal of Immunology·A RolinkF Melchers
Apr 1, 1995·The Journal of Experimental Medicine·U von Freeden-JeffryR Murray
Apr 14, 1995·Science·P J Casey
Apr 21, 1995·Science·F PapavasiliouM C Nussenzweig
Jun 1, 1995·The Journal of Experimental Medicine·R CarsettiM C Lamers
Jul 1, 1993·The Journal of Experimental Medicine·K H GrabsteinP J Morrissey
Sep 27, 1996·The Journal of Biological Chemistry·S CassardC Bonnerot
Feb 1, 1997·Current Biology : CB·L NitschkeM C Lamers
Jan 1, 1997·Annual Review of Immunology·M Reth, J Wienands
May 23, 1998·Annual Review of Immunology·J I Healy, C C Goodnow
Oct 1, 1998·European Journal of Immunology·M M Rosado, A A Freitas
Jan 19, 1999·Annual Review of Cell and Developmental Biology·D A Brown, E London
May 14, 1999·Current Opinion in Immunology·R J Benschop, J C Cambier
Jul 3, 1999·Science·K HayakawaR R Hardy
Dec 10, 1999·The Journal of Experimental Medicine·P C ChengS K Pierce
Apr 19, 2000·The Journal of Experimental Medicine·B C WeintraubC C Goodnow
Jun 3, 2000·Annual Review of Immunology·A A Freitas, B Rocha
Nov 21, 2000·The Journal of Experimental Medicine·M BattenF Mackay

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Citations

Jul 13, 2007·Immunological Reviews·Shannon M GrandeJohn G Monroe
Nov 3, 2011·Bone Marrow Research·Patricia Pérez-VeraEzequiel M Fuentes-Pananá
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ezequiel M Fuentes-PananáJohn G Monroe
Sep 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng Peng, Laurel A Eckhardt
Jun 25, 2017·Blood·Ondrej HavranekR Eric Davis
Mar 20, 2020·The Journal of Clinical Investigation·Christian HurtzSarah K Tasian
Jun 19, 2008·The Journal of General Virology·Leah J Anderson, Richard Longnecker
Oct 14, 2014·BioMed Research International·A Morales-SánchezE M Fuentes-Pananá
Mar 25, 2006·Nature Reviews. Immunology·John G Monroe
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ezequiel M Fuentes-PananáJohn G Monroe
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Craig D MilneChristopher J Paige
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·F Betul GulogluChristopher A J Roman
Oct 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristen L HoekWasif N Khan

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