PMID: 376776Jun 1, 1979Paper

Basal lamina heterogeneity in the glomerular capillary tufts of human kidneys

The Journal of Experimental Medicine
T W Huang

Abstract

Two classes of glomerular basal laminas are identified with a newly developed guanidine technique. The electron-opaque epithelial basal lamina is the most prominent element of the glomerular basal lamina scaffold. It is a continuous layer within each glomerulus, folding into capillary tufts and loops, but never completely encircling the entire circumference of each capillary, similar to the serosa covering the intestinal loop and mesentery. The vascular space so defined is further partitioned into individual capillary lumen by an electron-lucent mesangial basal lamina, that forms a meshwork continuous with the vascular pole of the glomerulus and extends peripherally to surround capillary lumens. The latter, designated endothelial basal lamina, is extremely attenuated and appears as a vestigial structure in glomerular capillary loops. Changes in juxtamesangial epithelial basal lamina indicate that it may be the site of the bulk removal and renewal of the epithelial basal lamina. The unique epithelial origin of glomerular capillary basal lamina and its organization provide a structural basis for understanding the glomerular physiology gained by various tracer studies. The results also suggest that the guanidine technique may be a...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B V HowardN A Kefalides
Aug 23, 1976·Biochemical and Biophysical Research Communications·E ChungE J Miller
Jun 1, 1975·European Journal of Biochemistry·M E GrantI F Williams
May 1, 1972·The Journal of Cell Biology·N SimionescuG E Palade
May 1, 1972·The Journal of Clinical Investigation·S M MauerA F Michael
Apr 2, 1973·Biochemical and Biophysical Research Communications·M L Tanzer, N A Kefalides
Jul 1, 1953·The Journal of Pathology and Bacteriology·B CRUICKSHANK, A G HILL
Jan 1, 1961·The Journal of Experimental Medicine·M G FARQUHARG E PALADE
May 1, 1962·The Journal of Pediatrics·R L VERNIER, A BIRCH-ANDERSEN

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Citations

May 1, 1994·Microscopy Research and Technique·F L Chan, S Inoue
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C E KashtanA J Fish
Jan 1, 1982·Springer Seminars in Immunopathology·P D KillenG E Striker
Jan 1, 1984·Developmental Biology·H SariolaP Ekblom
Jul 1, 1995·Acta histochemica·G MagroC Emmanuele
Jul 1, 1985·The Journal of Experimental Medicine·T W Huang, J C Langlois
Jan 1, 1997·Ryōikibetsu shōkōgun shirīzu·I Kihara
Nov 1, 1981·Journal of Clinical Pathology·D B Moffat
Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H MakinoZ Ota
Feb 1, 1980·Kidney International·A F MichaelS M Mauer
Apr 1, 1988·The American Journal of Anatomy·S Inoue, C P Leblond
Jan 1, 1981·Australian and New Zealand Journal of Medicine·A F Michael
Jun 21, 2019·Royal Society Open Science·Shinji Sassa, Soonbo Yang
Jan 1, 1983·Ultrastructural Pathology·R Sinniah, J Churg
Mar 27, 2021·Nature Reviews. Nephrology·Sébastien J DumasPeter Carmeliet
Mar 1, 1992·Kidney International·L Sorokin, P Ekblom

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